Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator
The article "Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system…
CertaraAugust 26, 2024
Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH)
The article “Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL)…
CertaraAugust 26, 2024
How does a clinical development plan help drug programs?
How important is a clinical development plan? Your biotechnology start-up’s candidate asset has an intriguing…
CertaraJuly 26, 2024
A guide to developing population files for physiologically-based pharmacokinetic modeling in the Simcyp Simulator
This collaborative effort by Certara and the Centre for Applied Pharmacokinetic Research (CAPKR) at The…
CertaraJuly 24, 2024
A literature review of drug transport mechanisms during lactation
The literature review titled "A literature review of drug transport mechanisms during lactation," authored by…
CertaraJuly 7, 2024
Reflections on the New FDA Clinical Pharmacology Guidance for Antibody-Drug Conjugates
In recent years, oncology drug developers have invested in antibody-drug conjugates (ADCs). These targeted therapies…
CertaraMay 10, 2024
Everything You Need to Know About SDTM
Find out all you need to know about CDISC SDTM, from the SDTM implementation guide…
CertaraMarch 12, 2024
Guide to development of compound files for PBPK modeling in the Simcyp population-based simulator
The Simcyp Simulator is a software platform for population physiologically-based pharmacokinetic (PBPK) modeling and simulation.…
CertaraFebruary 23, 2024
Interlaboratory Variability in the Madin–Darby Canine Kidney Cell Proteome
Madin–Darby canine kidney (MDCK) cells are widely used to study epithelial cell functionality. Their low…
CertaraJune 28, 2023
