Piet van der Graaf on AI and AI-assisted approaches in drug discovery & development Video Piet van der Graaf on AI and AI-assisted approaches in drug discovery & development At the 2024 AAPS PharmSci 360 conference, Bioanalysis Zone interviewed Piet van der Graaf, Senior…CertaraDecember 10, 2024
Informing pregnancy dose via target-mediated drug disposition modeling and simulations for a recombinant human monoclonal antibody Publication Informing pregnancy dose via target-mediated drug disposition modeling and simulations for a recombinant human monoclonal antibody The article titled "Informing pregnancy dose via target-mediated drug disposition modeling and simulations for a…CertaraNovember 4, 2024
Using PBPK modeling to supplement clinical data and support the safe and effective use of dolutegravir in pregnant and lactating women Publication Using PBPK modeling to supplement clinical data and support the safe and effective use of dolutegravir in pregnant and lactating women The article titled "Using PBPK modeling to supplement clinical data and support the safe and…CertaraOctober 30, 2024
A close examination of BCRP’s role in lactation and methods for predicting drug distribution into milk Publication A close examination of BCRP’s role in lactation and methods for predicting drug distribution into milk The article, authored by Caroline Sychterz, Hong Shen, Yueping Zhang, Michael Sinz, Amin Rostami-Hodjegan, Brian…CertaraSeptember 18, 2024
A tutorial on physiologically based pharmacokinetic approaches in lactation research Publication A tutorial on physiologically based pharmacokinetic approaches in lactation research The tutorial by Amita Pansari, Xian Pan, Lisa M. Almond, and Karen Rowland-Yeo examines the…CertaraSeptember 16, 2024
Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator Publication Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator The article "Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system…CertaraAugust 26, 2024
Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH) Publication Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH) The article “Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL)…CertaraAugust 26, 2024
A guide to developing population files for physiologically-based pharmacokinetic modeling in the Simcyp Simulator Publication A guide to developing population files for physiologically-based pharmacokinetic modeling in the Simcyp Simulator This collaborative effort by Certara and the Centre for Applied Pharmacokinetic Research (CAPKR) at The…CertaraJuly 24, 2024
A literature review of drug transport mechanisms during lactation Publication A literature review of drug transport mechanisms during lactation The literature review titled "A literature review of drug transport mechanisms during lactation," authored by…CertaraJuly 7, 2024
Guide to development of compound files for PBPK modeling in the Simcyp population-based simulator Publication Guide to development of compound files for PBPK modeling in the Simcyp population-based simulator The Simcyp Simulator is a software platform for population physiologically-based pharmacokinetic (PBPK) modeling and simulation.…CertaraFebruary 23, 2024