A tutorial on physiologically based pharmacokinetic approaches in lactation research

The tutorial by Amita Pansari, Xian Pan, Lisa M. Almond, and Karen Rowland-Yeo examines the application of physiologically-based pharmacokinetic (PBPK) modeling in lactation research, emphasizing its significance in predicting drug exposure for breastfeeding mothers and their infants. It discusses the challenges of managing medical conditions during lactation, particularly concerning medication safety and efficacy. The authors highlight the need for comprehensive data on drug transfer into breast milk, especially with recent regulatory changes promoting the inclusion of lactating women in clinical trials. By exploring milk composition dynamics and practical applications of PBPK modeling, the tutorial aims to enhance understanding and support informed decision-making in clinical scenarios involving breastfeeding mothers.