Publication

Effects of plateau hypoxia on population pharmacokinetics and pharmacodynamics of metformin in patients with Type 2 diabetes

Explore how high‑altitude hypoxia increases metformin AUC and half‑life; PK‑PD modelling supports extended dosing intervals.

CertaraApril 28, 2023

Publication

Optimization of polymyxin B regimens for the treatment of carbapenem-resistant organism nosocomial pneumonia: a real-world prospective study

Discover how AUC/MIC ≥ 66.9 predicts efficacy; modelling supports 75–100 mg q12h dosing for CRO…

CertaraApril 28, 2023

Publication

Tumor Dynamic Model-Based Decision Support for Phase Ib/II Combination Studies: A Retrospective Assessment Based on Resampling of the Phase III Study IMpower150

Explore how tumor growth inhibition modeling can support go/no-go decisions in early Phase Ib/II oncology…

CertaraMarch 24, 2023

Publication

Comparative Bioequivalence of Tablet and Capsule Formulations of Ulotaront and the Effect of Food on the Pharmacokinetics of the Tablet Form in Humans

See how tablet and capsule are bioequivalent; food delays Tmax without affecting exposure, analysed using…

CertaraMarch 17, 2023

Publication

Population pharmacokinetics and limited sampling strategies of polymyxin B in critically ill patients

Learn how PopPK modelling supports limited sampling strategies and individualized polymyxin B dosing using Phoenix…

CertaraMarch 2, 2023

Publication

Simultaneous pharmacokinetic assessment of phytopharmaceuticals in fenugreek extract using LC-MS/MS in Sprague-Dawley rats

Simultaneous PK profiling of four fenugreek phytochemicals in rats, supporting development of fenugreek‑based formulations by…

CertaraFebruary 27, 2023

Publication

Population pharmacokinetic analysis of TQ-B3203 following intravenous administration of TQ-B3203 liposome injection in Chinese patients with advanced solid tumors

See how PopPK modelling shows bilirubin, BMI, and lean body weight meaningfully affect TQ‑B3203 clearance…

CertaraJanuary 16, 2023

Publication

Pharmacokinetics and Bioequivalence of the Lubiprostone Capsule in Healthy Chinese Subject

Learn how dose‑proportional PK and fed‑state bioequivalence confirmed for lubiprostone using Phoenix WinNonlin.

CertaraJanuary 10, 2023

Publication

Population pharmacokinetics and limited sampling strategy for therapeutic drug monitoring of mycophenolate mofetil in Japanese patients with lupus nephritis

Find out how renal function and albumin drive MPA clearance; 1–4 h sampling best predicts…

CertaraJanuary 9, 2023

Publication

Population Pharmacokinetics and Dosing Regimen Optimization of Linezolid in Cerebrospinal Fluid and Plasma of Post-operative Neurosurgical Patients

Explore how highly variable CSF penetration; PopPK modelling supports renal‑ and inflammation‑adjusted dosing using Phoenix…

CertaraDecember 22, 2022

Clinical Pharmacology

Effects of plateau hypoxia on population pharmacokinetics and pharmacodynamics of metformin in patients with Type 2 diabetes

Optimization of polymyxin B regimens for the treatment of carbapenem-resistant organism nosocomial pneumonia: a real-world prospective study

Tumor Dynamic Model-Based Decision Support for Phase Ib/II Combination Studies: A Retrospective Assessment Based on Resampling of the Phase III Study IMpower150

Comparative Bioequivalence of Tablet and Capsule Formulations of Ulotaront and the Effect of Food on the Pharmacokinetics of the Tablet Form in Humans

Population pharmacokinetics and limited sampling strategies of polymyxin B in critically ill patients

Simultaneous pharmacokinetic assessment of phytopharmaceuticals in fenugreek extract using LC-MS/MS in Sprague-Dawley rats

Population pharmacokinetic analysis of TQ-B3203 following intravenous administration of TQ-B3203 liposome injection in Chinese patients with advanced solid tumors

Pharmacokinetics and Bioequivalence of the Lubiprostone Capsule in Healthy Chinese Subject

Population pharmacokinetics and limited sampling strategy for therapeutic drug monitoring of mycophenolate mofetil in Japanese patients with lupus nephritis

Population Pharmacokinetics and Dosing Regimen Optimization of Linezolid in Cerebrospinal Fluid and Plasma of Post-operative Neurosurgical Patients

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