The Protein Degrader Model Pack offers a comprehensive suite of quantitative systems pharmacology (QSP) models tailored for PROTAC and Molecular Glue Degrader pharmacologies. This pre-built model pack is used with Certara IQ™, and it supports precise predictions and informed decision-making in the development of protein degraders.
Protein Degrader Model Pack
Pre-built library of validated QSP models for PROTACs and molecular glue degraders
QSP Models for Protein Degraders
Four models covering in vivo and in vitro pharmacologies
Includes PROTAC and Molecular Glue Degrader targeting intracellular proteins
Default parameter values based on expansive literature searches
Model diagrams and parameters
Each model in the Protein Degrader Model Pack includes a mechanism of action diagram and a pharmacology diagram with model parameters and their nominal values. Each model in Certara IQ has a unique set of parameters, based on the model pharmacology and number of compartments. In the app, each parameter contains a default value based on expansive literature searches and references.
Created in Biorender
Explore other Certara IQ QSP model packs
In addition to the Protein Degrader model pack, Certara IQ offers several libraries of monospecific and bispecific, single-compartment and multicompartment models covering common pharmacologies.
Download the Protein Degrader model pack
Discover how the Protein Degrader Model Pack can accelerate development of PROTACs and molecule glue degrader modalities.
Gain insights into PROTAC and Molecular Glue Degrader pharmacologies
Access validated models with default parameter values
Optimize drug development with in vivo and in vitro simulations
Certara IQ Support
Have questions about how model pack libraries accelerate modeling in Certara IQ?
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