Phoenix Modeling Language School

Learn How to Build Custom PK and PK/PD Models

Phoenix WinNonlin® uses Phoenix Modeling Language (PML) to encode pharmacokinetic (PK) and Pharmacodynamic (PD) models. Although most models can be built using the graphical user interface (GUI) in Phoenix, there are some models that require custom coding with PML.

Certara has launched a series of interactive educational webinars to teach users how to build PK and PK/PD models in Phoenix. This series is called the Phoenix Modeling Language School or PML School. The series will cover scenarios such as simultaneous fitting of IV and PO data, target-mediated drug disposition, enterohepatic recirculation, tumor growth inhibition, and others and sessions are complimentary for Phoenix users.

Attendees will be able to ask questions and discuss how PML works after a brief tutorial. Questions can be submitted upon registration. After each seminar the lesson PML text code and presentation materials will be available for download from the Certara Support Forum. The recorded webinar will be available on the Certara Support Forum, so please make sure to sign up for the forum.

2017 PML School Schedule

PML-School-Date-Jan19 Enterohepatic Recirculation
Model enterohepatic recirculation (EHC) after intravenous administration
January 19, 2017 | 10am EST
Presenter: Bernd Wendt
PML-School-Date-Feb2 One-compartment 1st and 0-order Input
Fit and discriminate between first and zero-order absorption models
February 2, 2017 | 10am EST
Presenter: Chris Mehl
PML-School-Date-Feb16 Allometry-Elementary/Complex Dedrick Plot
Simultaneously fit an allometric model to data from mouse, rat and man
February 16, 2017 | 10am EST
Presenter: Dan Weiner
PML-School-Date-Mar2 Turnover III: Nonlinear Disposition
Characterize turnover of an endogenous compound
March 2, 2017 | 10am EST
Presenter: Bernd Wendt
 PML-School-Date-Mar16 Analysis and Comparison of Link, Turnover and Receptor Binding Models
Fit a link-, turnover- and receptor binding model to data
March 16, 2017 | 10am EST
Presenter: Dan Weiner
 PML-School-Date-Mar30 Sigmoidal Concentration-response Models
Apply Gompertz, Weibull, Richards, Morgan-Mercer-Flodin, Hill and logistic models
March 30, 2017 | 10am EST
Presenter: Chris Mehl
 PML-School-Date-Apr13 Analysis of a Tissue Growth/Kill Model
Analyze a tumor cell kill model after acute dosing
April 13, 2017 | 10am EST
Presenter: Bernd Wendt
 PML-School-Date-Apr27 Modeling Inhibition of Enzyme Activity by Means of Turnover
Construction of a mechanistic turnover model
April 27, 2017 | 10am EST
Presenter: Chris Mehl
 PML-School-Date-May11 Effect Compartment III: IV infusion
Model response-time data with a link-model
May 11, 2017 | 10am EST
Presenter: Bernd Wendt
 PML-School-Date-Jun8 Turnover Model 1: IV Bolus Dosing
Model Warfarin-PCA interaction
June 8, 2017 | 10am EST
Presenter: Chris Mehl
 PML-School-Date-Jun22 Turnover Model 4: IV Infusions
Apply a turnover model to multiple IV dosing response data
June 22, 2017 | 10am EST
Presenter: Bernd Wendt
 PML-School-Date-Jul13 Turnover Model 1: Repeated Dosing I
Apply a turnover model to repeated po dosing response data
July 13, 2017 | 10am EST
Presenter: Chris Mehl
 PML-School-Date-Jul27 Dose-response-time Analysis I-IV
Analyze dose-response-time data with an instantenous effect model
July 27, 2017 | 10am EST
Presenter: Bernd Wendt
 PML-School-Date-Aug10 Transduction Modeling: Assessment of Number of Transit Compartments
Analyze a transduction rate limited response time course
August 10, 2017 | 10am EST
Presenter: Bernd Wendt

About Our Speakers

Webinar-3speaker-Wendt-Mehl-WeinerDr. Bernd Wendt has been teaching as a trainer at Certara and is a lecturer at the Ludwig-Maximilians-Universität (Munich) for more than 5 years, providing seminars in pharmacokinetics and molecular modeling. He is currently heading the global support group at Certara.

Christopher Mehl is the Customer Support Manager, and is a software trainer at Certara since 2003. He has conducted over 200 training courses with Pharsight desktop products such as Phoenix WinNonlin, IVIVC, NLME, PKS, and Trial Simulator. These include workshops at the US Food and Drug Administration, universities, customer sites, and courses open to the public.

Dr. Daniel Weiner is the co-author of Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, now in its 5th ed. Dr. Weiner is an Adjunct Associate Professor with Division of Pharmacotherapy and Experimental Therapeutics in the School of Pharmacy, University of North Carolina and is an Affiliate Professor of Pharmacometrics, Center for Translational Medicine in the School of Pharmacy at the University of Maryland. During his career he has provided PK/PD training to over 2,000 students.

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