Model‐Informed Drug Repurposing: Viral Kinetic Modeling to Prioritize Rational Drug Combinations for COVID‐19

We hypothesized that viral kinetic modeling could be helpful to prioritize rational drug combinations for COVID‐19. The aim of this research was to use a viral cell cycle model of SARS‐CoV‐2 to explore the potential impact of drugs, or combinations of drugs that act at different stages in the viral life cycle might have on various metrics of infection outcome relevant in the early stages of COVID‐19 disease…

Author(s): Michael G. Dodds, Rajesh Krishna, Antonio Goncalves, Craig R. Rayner

Year: July 21, 2020