Basic Concepts in Physiologically-based Pharmacokinetic Modeling in Drug Discovery and Development
The aim of this tutorial is to introduce the concept of physiologically based pharmacokinetic (PBPK)…
CertaraAugust 1, 2013
Pfizer Deploys Certara’s D360 for Scientific Data Access and Analysis
Bio-IT World News Bulletin describes how Pfizer has adopted D360 as Pfizer’s core research platform. …
CertaraJuly 29, 2013
Clinical Trial Simulation to Inform Phase 2: Comparison of Concentrated vs. Distributed First-in-patient Study Designs in Psoriasis
Clinical trial simulation (CTS) and model-based meta-analysis (MBMA) can increase our understanding of small, first-in-patient…
CertaraJuly 24, 2013
A Mechanistic Framework for In Vitro-In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug-drug Interaction Between Rosuvastatin and Cyclosporine
The interplay between liver metabolizing enzymes and transporters is a complex process involving system-related parameters such as liver blood perfusion…
CertaraJuly 24, 2013
Model-based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development
The pharmaceutical industry continues to face significant challenges. Very few compounds that enter development reach…
CertaraJuly 1, 2013
The Simcyp Population-based Simulator: Architecture, Implementation, and Quality Assurance
Developing a user-friendly platform that can handle a vast number of complex physiologically based pharmacokinetic…
CertaraJune 3, 2013
Intravenous Topiramate: Safety and Pharmacokinetics Following a Single Dose in Patients with Epilepsy or Migraines Taking Oral Topiramate
Although topiramate is widely prescribed for epilepsy and migraine, there is no intravenous product. We…
CertaraJune 1, 2013
Intravenous Topiramate: Comparison of Pharmacokinetics and Safety with the Oral Formulation in Healthy Volunteers
Although oral topiramate (TPM) products are widely prescribed for migraines and epilepsy, injectable TPM is not available…
CertaraJune 1, 2013
