Page 171 | Certara

Publication

Pharmacokinetic and Pharmacodynamic Modeling to Determine the Human Dose of ST-246(R) to Protect Against Smallpox

Although smallpox has been eradicated, the United States government considers it a "material threat" and…

CertaraMarch 1, 2013

Publication

Predicting Drug-drug Interactions: Application of Physiologically-based Pharmacokinetic Models Under a Systems Biology Approach

The development of in vitro-in vivo extrapolation (IVIVE), a 'bottom-up' approach, to predict pharmacokinetic parameters…

CertaraMarch 1, 2013

Publication

In Vitro to Human In Vivo Translation—Pharmacokinetics and Pharmacodynamics of Quinidine

The translational sciences aim to transfer results from basic research to the treatment of animals…

CertaraMarch 1, 2013

Publication

Application of Knockout Mouse Models to Investigate the Influence of FcγR on the Pharmacokinetics and Anti-platelet Effects of MWReg30, a Monoclonal Anti-GPIIb Antibody

This work evaluates the influence of FcγR on the pharmacokinetics and pharmacodynamics of a rat…

CertaraFebruary 28, 2013

Knowledge Base

Saturable Drug Absorption

Drug absorption is the process by which a drug molecule moves from the site of…

CertaraFebruary 26, 2013

Publication

Systems Pharmacology of the Nerve Growth Factor Pathway: Use of a Systems Biology Model for the Identification of Key Drug Targets Using Sensitivity Analysis and the Integration of Physiology and Pharmacology

The nerve growth factor (NGF) pathway is of great interest as a potential source of…

CertaraFebruary 21, 2013

Publication

Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan?

Systems pharmacology is an emerging approach that sets out to use quantitative concepts rooted in…

CertaraFebruary 20, 2013

Blog Knowledge Base

Nonlinear PK: What Does That Mean?

You may come across a phrase like the following and wonder what it means: “……

CertaraFebruary 17, 2013

Knowledge Base

Why Cmax is a Continuous Variable and Tmax is a Categorical Variable

The maximum observed concentration (Cmax) and the time of Cmax (tmax) are both obtained directly…

CertaraFebruary 11, 2013

Knowledge Base

What is Quantification Anyway?

Bioanalytical analysis is a fundamental tool for the pharmacokineticist. The results of a bioanalysis are…

CertaraFebruary 5, 2013

Pharmacokinetic and Pharmacodynamic Modeling to Determine the Human Dose of ST-246(R) to Protect Against Smallpox

Predicting Drug-drug Interactions: Application of Physiologically-based Pharmacokinetic Models Under a Systems Biology Approach

In Vitro to Human In Vivo Translation—Pharmacokinetics and Pharmacodynamics of Quinidine

Application of Knockout Mouse Models to Investigate the Influence of FcγR on the Pharmacokinetics and Anti-platelet Effects of MWReg30, a Monoclonal Anti-GPIIb Antibody

Saturable Drug Absorption

Systems Pharmacology of the Nerve Growth Factor Pathway: Use of a Systems Biology Model for the Identification of Key Drug Targets Using Sensitivity Analysis and the Integration of Physiology and Pharmacology

Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan?

Nonlinear PK: What Does That Mean?

Why Cmax is a Continuous Variable and Tmax is a Categorical Variable

What is Quantification Anyway?

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