Designing a Clinical Drug-drug Interaction Study
After a much longer delay that I expected, I am back to blogging on a…
CertaraOctober 29, 2012
What is Hysteresis in PK/PD Analysis?
I apologize to all my readers for such a long lapse between posts. After a…
CertaraOctober 26, 2011
How Can PK/PD Analysis Add Value to Patient Care?
In May 2011, T.J. Smith and B.E. Hillner published an opinion piece in the New…
CertaraJuly 11, 2011
What is Curve Stripping?
The process of curve stripping is used in both compartmental and non-compartmental analysis. Each pharmacokinetic…
CertaraJuly 6, 2011
What to Do with Those BLQs!
BLQ values are like those pimples we used to get as teenagers. They…
CertaraApril 6, 2011
The Difference Between Vd and Vss
There are many terms used to represent volume of distribution, but two common ones are…
CertaraMarch 31, 2011
What is Shrinkage?
In 2007, Mats Karlsson and Radojka Savic published a perspective in Clinical Pharmacology & Therapeutics…
CertaraMarch 29, 2011
Is a Monte Carlo Simulation an Exotic Drink?
The term “Monte Carlo simulation” is often used in the modeling and simulation literature with…
CertaraMarch 21, 2011
What is WinNonlin?
A reader suggested that I write a similar post about WinNonlin. Great idea! Thank you!…
CertaraMarch 16, 2011
What is the Difference Between Individual and Population PK?
Pharmacokinetic analysis is often broken into two areas … “PK” and “population PK”. Sometimes the…
CertaraMarch 14, 2011
