Knowledge Base Archives

Knowledge Base

Using Sampling “Windows” for PK Blood Samples

One of the most common questions posed by clinical operations experts when including pharmacokinetic sampling…

CertaraOctober 15, 2013

Blog Knowledge Base

Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body

When I first began learning about pharmacokinetics, I was often confused by the mean residence…

CertaraMarch 28, 2013

Knowledge Base

The Superposition Principle

Discover the superposition principle and its significance in science and mathematics. Learn how this fundamental…

CertaraMarch 14, 2013

Knowledge Base

Saturable Drug Absorption

Drug absorption is the process by which a drug molecule moves from the site of…

CertaraFebruary 26, 2013

Blog Knowledge Base

Nonlinear PK: What Does That Mean?

You may come across a phrase like the following and wonder what it means: “……

CertaraFebruary 17, 2013

Knowledge Base

Why Cmax is a Continuous Variable and Tmax is a Categorical Variable

The maximum observed concentration (Cmax) and the time of Cmax (tmax) are both obtained directly…

CertaraFebruary 11, 2013

Knowledge Base

What is Quantification Anyway?

Bioanalytical analysis is a fundamental tool for the pharmacokineticist. The results of a bioanalysis are…

CertaraFebruary 5, 2013

Blog Knowledge Base

Calculating Urine PK Parameters

Pharmacokinetic analysis normally focuses on systemic exposure to a drug; however, much can be learned…

CertaraDecember 6, 2012

Knowledge Base

What Can We Learn from a Human Mass Balance Study?

Mass balance studies are also called “C-14 studies” or “Absorption, Metabolism, and Excretion (AME) studies”.…

CertaraNovember 27, 2012

Blog Knowledge Base

Bioavailability

Discover bioavailability in pharmacokinetics, its types, the first-pass effect, and calculations. Explore tools for accurate…

CertaraNovember 4, 2012

Knowledge Base

Using Sampling “Windows” for PK Blood Samples

Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body

The Superposition Principle

Saturable Drug Absorption

Nonlinear PK: What Does That Mean?

Why Cmax is a Continuous Variable and Tmax is a Categorical Variable

What is Quantification Anyway?

Calculating Urine PK Parameters

What Can We Learn from a Human Mass Balance Study?

Bioavailability

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