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Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body

When I first began learning about pharmacokinetics, I was often confused by the mean residence…

CertaraMarch 28, 2013

Blog Knowledge Base

Nonlinear PK: What Does That Mean?

You may come across a phrase like the following and wonder what it means: “……

CertaraFebruary 17, 2013

Blog Knowledge Base

Calculating Urine PK Parameters

Pharmacokinetic analysis normally focuses on systemic exposure to a drug; however, much can be learned…

CertaraDecember 6, 2012

Blog Knowledge Base

Bioavailability

Discover bioavailability in pharmacokinetics, its types, the first-pass effect, and calculations. Explore tools for accurate…

CertaraNovember 4, 2012

Blog Knowledge Base

What to Do with Those BLQs!

BLQ values are like those pimples we used to get as teenagers. They…

CertaraApril 6, 2011

Blog Knowledge Base

The Difference Between Vd and Vss

There are many terms used to represent volume of distribution, but two common ones are…

CertaraMarch 31, 2011

Blog Knowledge Base

Why Should You Evaluate Dose Proportionality?

Dose proportionality is a common phrase used pharmacokinetics. Early in the pre-clinical development process, we…

CertaraFebruary 17, 2011

Blog Knowledge Base

Where Did the 80-125% Bioequivalence Criteria Come From?

Most people involved in clinical pharmacokinetics are familiar with the 80-125% criterion. This criterion is…

CertaraJanuary 24, 2011

Blog Knowledge Base

Trial Designs—Non-inferiority vs. Superiority vs. Equivalence

The primary purpose of a clinical trial is to address a scientific hypothesis. To address…

CertaraJanuary 1, 2011

Blog Knowledge Base

Understanding Volume of Distribution

CertaraJune 5, 2010

Blog

Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body

Nonlinear PK: What Does That Mean?

Calculating Urine PK Parameters

Bioavailability

What to Do with Those BLQs!

The Difference Between Vd and Vss

Why Should You Evaluate Dose Proportionality?

Where Did the 80-125% Bioequivalence Criteria Come From?

Trial Designs—Non-inferiority vs. Superiority vs. Equivalence

Understanding Volume of Distribution

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