PK/PD Modeling & Simulation

Bioanalysis from a PK Perspective

Nathan Teuscher

The field of bioanalytical chemistry, or bioanalysis, is an important area of research that has a direct impact on the work of pharmacokineticists. Essentially, bioanalysis converts a blood sample (or any other matrix) into a drug concentration by the use of analytical equipment. Over the next few weeks, I would like to cover a variety […]

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Topics: PK/PD Modeling & Simulation

What Can We Learn from Dose Normalization?

Nathan Teuscher

Dose normalization is a common calculation performed with pharmacokinetic parameters. The general process is to divide the PK parameters by the administered dose. This is performed for each individual or treatment group in a study, and then comparisons of dose-normalized parameters can be performed. But, why would we want to dose normalize PK parameters? What […]

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Topics: PK/PD Modeling & Simulation

Value Focused Development

Leigh Farrell

When we are engaged in conversations about developing medicines, how often do you hear language thrown around such as “capturing the value,” “fast to the next value inflection point,” or words to this effect? Drug development is a complex and risky business where remuneration for value creation occurs, by analogy, by passing the baton from […]

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Topics: Clinical Pharmacology Strategy

Extrapolating AUC to Infinity

Nathan Teuscher

Area under the curve or AUC is a pharmacokinetic statistic used to describe the total exposure to a drug. More specifically, it is the time-averaged concentration of drug circulating in the body fluid analyzed (normally plasma, blood or serum). Standard calculation of AUC involves using non-compartmental techniques to calculate the AUC from time 0 to […]

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Topics: PK/PD Modeling & Simulation

Simplifying Deconvolution

Nathan Teuscher

Deconvolution is used to evaluate the absorption kinetics of a drug. Unfortunately the term can be confusing and explanations are generally even more confusing. While deconvolution is not a simple topic, I believe it can be understood so that more scientists can apply the principles to their work. Before I define deconvolution, let me define […]

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Topics: PK/PD Modeling & Simulation
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