Month: May 2014
Lost in Centrifugation! Accounting for Transporter Protein Losses in Quantitative Targeted Absolute Proteomics (QTAP)
Investigating the Mechanism of Acamprosate Intestinal Absorption by the Use of In Vitro Transporter Studies in Combination with Modeling and Simulations
Challenges in the Modeling of Bidirectional Transport Experiments
Model-based Meta-analysis for Quantifying Paclitaxel Dose Response in Cancer Patients
Model-based meta-analysis of dose response is a sophisticated method to guide dose and regimen selection. In this report, the effects of paclitaxel dose and regimen (weekly or every 3 weeks) on the efficacy and safety in cancer patients were quantified by model-based meta-analysis of 29 monotherapy trials. Logistic regression models were developed to assess the … Continued
A Mechanistic Model to Predict Subcutaneous Absorption of Therapeutic Proteins Linked to a Whole Body PBPK Model
A Semi-mechanistic Model to Predict Renal Clearance of Therapeutic Proteins Linked to a Whole Body PBPK Model
What Can We Learn from Dose Normalization?
Dose normalization is a common calculation performed with pharmacokinetic parameters. The general process is to divide the PK parameters by the administered dose. This is performed for each individual or treatment group in a study, and then comparisons of dose-normalized parameters can be performed. But, why would we want to dose normalize PK parameters? What … Continued
Modeling the Binding Kinetics of Bispecific Antibodies under the Framework of a Minimal Human PBPK Model
Creating Templates in Phoenix WinNonlin
One of the most useful features of the new Phoenix WinNonlin software is the ability to re-use objects for new projects. In particular, it takes quite a bit of time to adjust all of the settings for figures in Phoenix. You need to adjust the font on both axes, change the legend labels, choose the … Continued