Clinical Trial Simulations in Pediatric Patients Using Realistic Covariates: Application to Teduglutide, a Glucagon-like Peptide-2 Analog in Neonates and Infants with Short-bowel Syndrome Publication Clinical Trial Simulations in Pediatric Patients Using Realistic Covariates: Application to Teduglutide, a Glucagon-like Peptide-2 Analog in Neonates and Infants with Short-bowel Syndrome Teduglutide, a synthetic glucagon-like peptide-2 (GLP-2) analog with activity relating to the regeneration, maintenance, and…CertaraDecember 1, 2009
In Vitro Inhibition of Multiple Cytochrome P450 Isoforms by Xanthone Derivatives from Mangosteen Extract Publication In Vitro Inhibition of Multiple Cytochrome P450 Isoforms by Xanthone Derivatives from Mangosteen Extract Mangosteen is a xanthone-containing fruit found in Southeast Asia for which health claims include maintaining healthy immune…CertaraSeptember 1, 2009
Model-based Prediction of Phase 3 Overall Survival in Colorectal Cancer on the Basis of Phase 2 Tumor Dynamics Publication Model-based Prediction of Phase 3 Overall Survival in Colorectal Cancer on the Basis of Phase 2 Tumor Dynamics We developed a drug-disease simulation model to predict antitumor response and overall survival in phase…CertaraSeptember 1, 2009
Excluding Venous Thromboembolism Using Point of Care D-dimer Tests in Outpatients: A Diagnostic Meta-analysis Publication Excluding Venous Thromboembolism Using Point of Care D-dimer Tests in Outpatients: A Diagnostic Meta-analysis This article is a review the evidence on the diagnostic accuracy of the currently available…CertaraAugust 14, 2009
On the Use of Change in Tumor Size to Predict Survival in Clinical Oncology Studies: Toward a New Paradigm to Design and Evaluate Phase 2 Studies Publication On the Use of Change in Tumor Size to Predict Survival in Clinical Oncology Studies: Toward a New Paradigm to Design and Evaluate Phase 2 Studies Drug-independent models that link biomarker response to clinical end points are critical to support early…CertaraAugust 1, 2009
Pharmacokinetic Analysis of Capsaicin After Topical Administration of a High-concentration Capsaicin Patch to Patients With Peripheral Neuropathic Pain Publication Pharmacokinetic Analysis of Capsaicin After Topical Administration of a High-concentration Capsaicin Patch to Patients With Peripheral Neuropathic Pain Capsaicin, a pungent compound in chili peppers, is a highly selective agonist for the transient…CertaraAugust 1, 2009
Population Pharmacokinetics of Intravenous Pantoprazole in Pediatric Intensive Care Patients Publication Population Pharmacokinetics of Intravenous Pantoprazole in Pediatric Intensive Care Patients What is already known about this subject The use of intravenous pantoprazole, a proton pump…CertaraFebruary 1, 2009
Pharmacokinetics, Safety, and Tolerability of Teduglutide, a Glucagon-like Peptide-2 (GLP-2) Analog, Following Multiple Ascending Subcutaneous Administrations in Healthy Subjects Publication Pharmacokinetics, Safety, and Tolerability of Teduglutide, a Glucagon-like Peptide-2 (GLP-2) Analog, Following Multiple Ascending Subcutaneous Administrations in Healthy Subjects Teduglutide, a glucagon-like peptide-2 (GLP-2) analog, is currently being evaluated for the treatment of short-bowel…CertaraNovember 1, 2008
Meta-analysis of the Diagnostic Accuracy of Transesophageal Echocardiography for Assessment of Atherosclerosis in the Ascending Aorta in Patients Undergoing Cardiac Surgery Publication Meta-analysis of the Diagnostic Accuracy of Transesophageal Echocardiography for Assessment of Atherosclerosis in the Ascending Aorta in Patients Undergoing Cardiac Surgery Stroke after cardiac surgery may be caused by emboli emerging from an atherosclerotic ascending aorta…CertaraOctober 1, 2008
Intestinal Metabolism and Transport of Drugs in Children: The Effects of Age and Disease Publication Intestinal Metabolism and Transport of Drugs in Children: The Effects of Age and Disease The presence of cytochrome P450 enzymes in the small bowel results in the reduced bioavailability…CertaraJuly 1, 2008