Therapeutic Specialties Archives

Publication

Population Pharmacokinetics of Intravenous Pantoprazole in Pediatric Intensive Care Patients

What is already known about this subject The use of intravenous pantoprazole, a proton pump…

CertaraFebruary 1, 2009

Publication

Pharmacokinetics, Safety, and Tolerability of Teduglutide, a Glucagon-like Peptide-2 (GLP-2) Analog, Following Multiple Ascending Subcutaneous Administrations in Healthy Subjects

Teduglutide, a glucagon-like peptide-2 (GLP-2) analog, is currently being evaluated for the treatment of short-bowel…

CertaraNovember 1, 2008

Publication

Meta-analysis of the Diagnostic Accuracy of Transesophageal Echocardiography for Assessment of Atherosclerosis in the Ascending Aorta in Patients Undergoing Cardiac Surgery

Stroke after cardiac surgery may be caused by emboli emerging from an atherosclerotic ascending aorta…

CertaraOctober 1, 2008

Publication

Intestinal Metabolism and Transport of Drugs in Children: The Effects of Age and Disease

The presence of cytochrome P450 enzymes in the small bowel results in the reduced bioavailability…

CertaraJuly 1, 2008

Publication

Pain Relief Model for a COX-2 Inhibitor in Patients with Postoperative Dental Pain

The aim of this study was to develop a pain relief model for a cyclooxygenase…

CertaraJuly 1, 2008

Publication

Development of CYP2D6 and CYP3A4 in the First Year of Life

Recently, Blake et al . ‘‘Ontogeny of dextromethorphan O- and N-demethylation in the first year…

CertaraMay 1, 2008

Publication

CYP2D6 is Primarily Responsible for the Metabolism of Clomiphene

Clomiphene is a first line treatment for anovulation, a common cause of infertility. Response to…

CertaraApril 30, 2008

Publication

Inactivation of CYP2D6 by Methylenedioxymethamphetamine in Different Recombinant Expression Systems

Recombinantly expressed CYP450 systems (rCYPs) are often used to screen for irreversible/quasi-irreversible enzyme inhibitors during…

CertaraSeptember 1, 2007

Publication

The Problems in Scaling Adult Drug Doses to Children

Many drugs are unlicensed in children and consequently their doses have been scaled down from…

CertaraMarch 15, 2007

Publication

Predictive Population Pharmacokinetic/Pharmacodynamic Model for a Novel COX-2 Inhibitor

The objectives of these analyses were to (1) develop a population pharmacokinetic/pharmacodynamic model for a…

CertaraMarch 1, 2007

Therapeutic Specialties

Population Pharmacokinetics of Intravenous Pantoprazole in Pediatric Intensive Care Patients

Pharmacokinetics, Safety, and Tolerability of Teduglutide, a Glucagon-like Peptide-2 (GLP-2) Analog, Following Multiple Ascending Subcutaneous Administrations in Healthy Subjects

Meta-analysis of the Diagnostic Accuracy of Transesophageal Echocardiography for Assessment of Atherosclerosis in the Ascending Aorta in Patients Undergoing Cardiac Surgery

Intestinal Metabolism and Transport of Drugs in Children: The Effects of Age and Disease

Pain Relief Model for a COX-2 Inhibitor in Patients with Postoperative Dental Pain

Development of CYP2D6 and CYP3A4 in the First Year of Life

CYP2D6 is Primarily Responsible for the Metabolism of Clomiphene

Inactivation of CYP2D6 by Methylenedioxymethamphetamine in Different Recombinant Expression Systems

The Problems in Scaling Adult Drug Doses to Children

Predictive Population Pharmacokinetic/Pharmacodynamic Model for a Novel COX-2 Inhibitor

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