pre-update Archives

Publication

Integrated In Vitro Analysis for the In Vivo Prediction of Cytochrome P450-mediated Drug-drug Interactions

Unbound IC50 (IC50,u) values of 15 drugs were determined in eight recombinantly expressed human cytochromes P450…

CertaraJune 1, 2008

Publication

Application of CYP3A4 In Vitro Data to Predict Clinical Drug-drug Interactions: Predictions of Compounds as Objects of Interaction

Numerous retrospective analyses have shown the utility of in vitro systems for predicting potential drug-drug interactions (DDIs). Prediction of DDIs…

CertaraMay 1, 2008

Publication

Development of CYP2D6 and CYP3A4 in the First Year of Life

Recently, Blake et al . ‘‘Ontogeny of dextromethorphan O- and N-demethylation in the first year…

CertaraMay 1, 2008

Publication

CYP2D6 is Primarily Responsible for the Metabolism of Clomiphene

Clomiphene is a first line treatment for anovulation, a common cause of infertility. Response to…

CertaraApril 30, 2008

Publication

The Effects of CYP3A4 Inhibition on Erlotinib Pharmacokinetics: Computer-based Simulation (Simcyp) Predicts In Vivo Metabolic Inhibition

BACKGROUND: Erlotinib is an orally active antitumor agent. Analyses in vitro using human liver microsomes and…

CertaraJanuary 1, 2008

Publication

Physiologically-based Approaches Towards the Prediction of Pharmacokinetics: In Vitro-In Vivo Extrapolation

In adapting to the challenge to make more informed selection of compounds for development, the…

CertaraDecember 1, 2007

Publication

In Silico Elucidation of the Molecular Mechanism Defining the Adverse Effect of Selective Estrogen Receptor Modulators

Early identification of adverse effect of preclinical and commercial drugs is crucial in developing highly…

CertaraNovember 1, 2007

Publication

Comparison of Different Approaches to Predict Metabolic Drug-drug Interactions

Three approaches were compared to predict the actual magnitude of drug interaction (the mean fold-change in the area under…

CertaraOctober 1, 2007

Publication

Prediction of Intestinal First-pass Drug Metabolism

Despite a lower content of many drug metabolising enzymes in the intestinal epithelium compared to…

CertaraOctober 1, 2007

Publication

Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes

An analysis of reported hepatic abundances of CYP3A4 and 3A5 indicated that values determined by…

CertaraOctober 1, 2007

pre-update

Integrated In Vitro Analysis for the In Vivo Prediction of Cytochrome P450-mediated Drug-drug Interactions

Application of CYP3A4 In Vitro Data to Predict Clinical Drug-drug Interactions: Predictions of Compounds as Objects of Interaction

Development of CYP2D6 and CYP3A4 in the First Year of Life

CYP2D6 is Primarily Responsible for the Metabolism of Clomiphene

The Effects of CYP3A4 Inhibition on Erlotinib Pharmacokinetics: Computer-based Simulation (Simcyp) Predicts In Vivo Metabolic Inhibition

Physiologically-based Approaches Towards the Prediction of Pharmacokinetics: In Vitro-In Vivo Extrapolation

In Silico Elucidation of the Molecular Mechanism Defining the Adverse Effect of Selective Estrogen Receptor Modulators

Comparison of Different Approaches to Predict Metabolic Drug-drug Interactions

Prediction of Intestinal First-pass Drug Metabolism

Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes

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