What is Modeling and Simulation?
I am currently attending a short conference on modeling and simulation in pediatric clinical pharmacology,…
CertaraFebruary 1, 2011
Physiologically-based Pharmacokinetic Model for Topotecan in Mice
Topotecan is a chemotherapeutic agent of choice for the second-line treatment of recurrent ovarian cancer.…
CertaraFebruary 1, 2011
Excretion of the Principal Urinary Metabolites of Phenytoin and Absolute Oral Bioavailability Determined by Use of a Stable Isotope in Patients with Epilepsy
The anticonvulsant properties of phenytoin (PHT) were discovered in 1938. Since then, it has been…
CertaraFebruary 1, 2011
Poor Correlation between Urinary Excretion of the Principal Urinary Metabolites of Phenytoin and Absolute Oral Bioavailability Determined by a Stable Isotope Method in Epilepsy Patients
The anticonvulsant properties of phenytoin (PHT) were discovered in 1938. Since then, it has been…
CertaraFebruary 1, 2011
Physiologically-based Pharmacokinetics in Drug Development and Regulatory Science
The application of physiologically-based pharmacokinetic (PBPK) modeling is coming of age in drug development and…
CertaraFebruary 1, 2011
Unexpected Effect of Rifampin on the Pharmacokinetics of Linezolid: In Silico and In Vitro Approaches to Explain Its Mechanism
The effect of rifampin on the steady-state pharmacokinetics of linezolid was evaluated in an open-label,…
CertaraFebruary 1, 2011
Critique of the Two-fold Measure of Prediction Success for Ratios: Application for the Assessment of Drug-drug Interactions
Current assessment of drug-drug interaction (DDI) prediction success is based on whether predictions fall within a two-fold range of the observed data. This strategy…
CertaraFebruary 1, 2011
Applications of Physiologically-based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review
Physiologically based pharmacokinetic (PBPK) modeling and simulation is a tool that can help predict the…
CertaraFebruary 1, 2011
Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides
Polycyclic aromatic hydrocarbons (PAH) are among the likely major causative agents for lung cancer in…
CertaraFebruary 1, 2011
Meta-analysis of Thoracic Epidural Anesthesia Versus General Anesthesia for Cardiac Surgery
A combination of general anesthesia (GA) with thoracic epidural anesthesia (TEA) may have a beneficial…
CertaraFebruary 1, 2011
