Relationship Between AUC and Volume of Distribution
A few days ago on the pharmacokinetics listserve PharmPK, the following question appeared: I’m having…
CertaraJanuary 26, 2011
Where Did the 80-125% Bioequivalence Criteria Come From?
Most people involved in clinical pharmacokinetics are familiar with the 80-125% criterion. This criterion is…
CertaraJanuary 24, 2011
Generics and Bioequivalence
As the debate about health care in the United States continues forward, the term “generic…
CertaraJanuary 10, 2011
What are Compartmental Models?
Learn about compartmental models and their importance in pharmacokinetics. Find out how they simplify drug…
CertaraJanuary 5, 2011
What are Drug-drug Interactions Anyway?
A current buzz phrase in pharmaceutical research right now is “drug-drug interaction” or simply “drug…
CertaraJanuary 5, 2011
The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain
ATP-binding cassette transporters P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) have been shown to…
CertaraJanuary 1, 2011
Absorption Rate
The rate at which a drug enters the body after administration is called the absorption…
CertaraDecember 30, 2010
What is a Half-life?
One of the most incorrectly used but most often quoted parameters is half life. The…
CertaraDecember 20, 2010
Modeling Disease Progression in Acute Stroke Using Clinical Assessment Scales
This article demonstrates techniques for describing and predicting disease progression in acute stroke by modeling…
CertaraDecember 1, 2010
Development of a Modeling Framework to Simulate Efficacy Endpoints for Motesanib in Thyroid Cancer Patients
To develop a modeling framework that simulates clinical endpoints (objective response rate and progression-free survival)…
CertaraNovember 1, 2010
