What Does Clearance Mean?
Drug clearance is an extremely important topic in the science of pharmacokinetics. Drug clearance defines…
Nathan TeuscherJune 13, 2010
Understanding Volume of Distribution
One of the most misunderstood pharmacokinetic (PK) parameters is volume of distribution. First of all…
CertaraJune 5, 2010
Pharmacology and Safety of Glycerol Phenylbutyrate in Healthy Adults and Adults with Cirrhosis
Phenylbutyric acid (PBA), which is approved for treatment of urea cycle disorders (UCDs) as sodium…
Danielle PillsburyJune 1, 2010
What is Pharmacodynamics?
Starting with definitions is always helpful… so after defining pharmacokinetics, a definition for pharmacodynamics is…
Nathan TeuscherMay 24, 2010
What is Pharmacokinetics?
You might think this is a simple question, especially for an expert in pharmacokinetics. Well,…
Nathan TeuscherMay 16, 2010
Population Pharmacokinetic/Pharmacodynamic Model for a C.E.R.A. in Both ESA-naive and ESA-treated Chronic Kidney Disease Patients with Renal Anemia
This study aimed to develop a population pharmacokinetic/pharmacodynamic (PK/PD) model for C.E.R.A., a continuous erythropoietin…
Danielle PillsburyMay 1, 2010
Population Pharmacokinetics of Teduglutide Following Repeated Subcutaneous Administrations in Healthy Participants and in Patients with Short Bowel Syndrome and Crohn’s Disease
Teduglutide is a GLP-2 analog currently evaluated for the treatment of short bowel syndrome, Crohn's…
Danielle PillsburyJanuary 1, 2010
Clinical Trial Simulations in Pediatric Patients Using Realistic Covariates: Application to Teduglutide, a Glucagon-like Peptide-2 Analog in Neonates and Infants with Short-bowel Syndrome
Teduglutide, a synthetic glucagon-like peptide-2 (GLP-2) analog with activity relating to the regeneration, maintenance, and…
Danielle PillsburyDecember 1, 2009
Is a Thorough QTc Study Necessary? The Role of Modeling and Simulation in Evaluating the QTc Prolongation Potential of Drugs
Concentration-QT (C-QT) modeling has been conducted for multiple compounds at various stages of development in…
Danielle PillsburyNovember 1, 2009
Model-based Prediction of Phase 3 Overall Survival in Colorectal Cancer on the Basis of Phase 2 Tumor Dynamics
We developed a drug-disease simulation model to predict antitumor response and overall survival in phase…
Danielle PillsburySeptember 1, 2009
