Modeling and Simulation - PK/PD Archives | Page 29 of 38

Publication

Novel Biocompatible Disease Modifying Nanomedicine of VIP for Rheumatoid Arthritis

Despite advances in rheumatoid arthritis (RA) treatment, efficacious and safe disease-modifying therapy still represents an…

CertaraDecember 4, 2012

Knowledge Base

What Can We Learn from a Human Mass Balance Study?

Mass balance studies are also called “C-14 studies” or “Absorption, Metabolism, and Excretion (AME) studies”.…

CertaraNovember 27, 2012

Blog Knowledge Base

Bioavailability

Discover bioavailability in pharmacokinetics, its types, the first-pass effect, and calculations. Explore tools for accurate…

CertaraNovember 4, 2012

Publication

Simulations Using a Drug-disease Modeling Framework and Phase 2 Data Predict Phase 3 Survival Outcome in First-line Non-small Cell Lung Cancer

Simulations were performed for carboplatin/paclitaxel (C/P) plus motesanib or bevacizumab vs. C/P as first-line treatment…

CertaraNovember 1, 2012

Publication

Characterization of Exposure Versus Response of Edoxaban in Patients Undergoing Total Hip Replacement Surgery

Edoxaban is an oral direct factor Xa inhibitor approved for the prevention of venous thromboembolism…

CertaraNovember 1, 2012

Knowledge Base

Designing a Clinical Drug-drug Interaction Study

After a much longer delay that I expected, I am back to blogging on a…

CertaraOctober 29, 2012

Publication

Microdialysis Evaluation of Clozapine and N-desmethylclozapine Pharmacokinetics in Rat Brain

A significant barrier to realization of the full potential of clozapine as a therapeutic agent…

CertaraOctober 1, 2012

Publication

In Vivo-formed Versus Preformed Metabolite Kinetics of Trans-resveratrol-3-sulfate and Trans-resveratrol-3-glucuronide

Metabolites in safety testing have gained a lot of attention recently. Regulatory agencies have suggested…

CertaraOctober 1, 2012

Publication

Relationship Between Prenatal Exposure to Polychlorinated Biphenyls and Birth Weight: A Systematic Analysis of Published Epidemiological Studies Through a Standardization of Biomonitoring Data

Impact of prenatal PCB exposure on birth weight was investigated in various children cohorts and…

CertaraOctober 1, 2012

Publication

Phenanthrene Metabolism in Smokers: Use of a Two-step Diagnostic Plot Approach to Identify Subjects with Extensive Metabolic Activation

Polycyclic aromatic hydrocarbons (PAHs) in cigarette smoke are among the most likely causes of lung…

CertaraSeptember 1, 2012

Modeling and Simulation – PK/PD

Novel Biocompatible Disease Modifying Nanomedicine of VIP for Rheumatoid Arthritis

What Can We Learn from a Human Mass Balance Study?

Bioavailability

Simulations Using a Drug-disease Modeling Framework and Phase 2 Data Predict Phase 3 Survival Outcome in First-line Non-small Cell Lung Cancer

Characterization of Exposure Versus Response of Edoxaban in Patients Undergoing Total Hip Replacement Surgery

Designing a Clinical Drug-drug Interaction Study

Microdialysis Evaluation of Clozapine and N-desmethylclozapine Pharmacokinetics in Rat Brain

In Vivo-formed Versus Preformed Metabolite Kinetics of Trans-resveratrol-3-sulfate and Trans-resveratrol-3-glucuronide

Relationship Between Prenatal Exposure to Polychlorinated Biphenyls and Birth Weight: A Systematic Analysis of Published Epidemiological Studies Through a Standardization of Biomonitoring Data

Phenanthrene Metabolism in Smokers: Use of a Two-step Diagnostic Plot Approach to Identify Subjects with Extensive Metabolic Activation

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