Understanding LC/MS/MS
The most common bioanalytical method in use today is LC/MS/MS, or liquid chromatography (LC) tandem…
CertaraJuly 15, 2014
Population Pharmacokinetic Analysis of Dutogliptin, a Selective Dipeptidyl Peptidase-4 Inhibitor
Dutogliptin is a selective dipeptidyl peptidase-4 inhibitor shown to be efficacious and safe in patients…
CertaraJuly 14, 2014
Application of a Physiologically-based Pharmacokinetic Model to Predict OATP1B1-related Variability in Pharmacodynamics of Rosuvastatin
Typically, pharmacokinetic-pharmacodynamic (PK/PD) models use plasma concentration as the input that drives the PD model. However, interindividual variability in…
CertaraJuly 9, 2014
What is HPLC/UV?
In my series about bioanalysis for the pharmacokineticist, I thought I would start with the…
CertaraJuly 8, 2014
Population Pharmacokinetics and Bayesian Estimation of Tacrolimus Exposure in Pediatric Liver Transplant Recipients
Objectives of this study were to develop a population pharmacokinetic (PopPK) model for tacrolimus in…
CertaraJune 1, 2014
The ISoP Standards and Best Practices Committee
The mission of the International Society of Pharmacometrics (ISoP) Standards and Best Practices Committee is…
CertaraJune 1, 2014
Model-based Meta-analysis for Quantifying Paclitaxel Dose Response in Cancer Patients
Model-based meta-analysis of dose response is a sophisticated method to guide dose and regimen selection.…
CertaraMay 21, 2014
What Can We Learn from Dose Normalization?
Dose normalization is a common calculation performed with pharmacokinetic parameters. The general process is to…
CertaraMay 19, 2014
Evaluation of Tumor Size Response Metrics to Predict Survival in Oncology Clinical Trials
Model-based drug development in oncology is still lagging despite a good momentum in the clinical…
CertaraApril 1, 2014
