How Modeling and Simulation Can Bring New Immuno-oncology Treatments to Patients
Immuno-oncology, which harnesses the patient's own immune system to fight cancer, is one of the…
CertaraFebruary 16, 2016
Conventional & Mechanistic IVIVC: Complementary or Clashing Methods?
An IVIVC (in vitro-in vivo correlation) is a mathematical relationship that predicts key pharmacokinetic parameters…
CertaraFebruary 9, 2016
Altered Plasma Pharmacokinetics of Ceftiofur Hydrochloride in Cows Affected with Severe Clinical Mastitis
Mastitis is a frequent problem among dairy cows, reducing milk yield and increasing cull rates.…
CertaraJanuary 1, 2016
Back to the Future (of Pharmacometrics) with Dr. Lawrence Lesko
Pharmacometrics uses mathematical models of biology, pharmacology, disease, and physiology to describe and quantify interactions…
CertaraDecember 1, 2015
9 Frequently Misunderstood Concepts in PK/PD Modeling
In teaching pharmacometrics, I've noticed that scientists have difficulty with certain PK/PD modeling concepts. Maybe…
CertaraNovember 3, 2015
Population PK & Dosing Implications for Cobimetinib in Cancer Patients
A population pharmacokinetic model was developed for cobimetinib in cancer patients. Covariates had minimal impact…
CertaraNovember 1, 2015
Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model
Bioavailability of orally administered drugs can be influenced by a number of factors including release…
CertaraNovember 1, 2015
