On-Demand Webinar

On-ramps to popPK: Building Better Models with GUI, Code, or Both

A critical component of popPK studies is popPK modeling, where mathematical models are developed to…

CertaraOctober 18, 2024

Conference

16th Annual World ADC London 2026

CertaraOctober 11, 2024

Publication

A Pharmacokinetic/Toxicodynamic Model of Cisplatin Nephrotoxicity Using the Kidney Injury Molecule‑1 Biomarker

Discover how PK‑TD modelling shows palonosetron reduces platinum exposure and KIM‑1 elevations versus other antiemetics…

CertaraSeptember 20, 2024

Publication

A close examination of BCRP’s role in lactation and methods for predicting drug distribution into milk

The article, authored by Caroline Sychterz, Hong Shen, Yueping Zhang, Michael Sinz, Amin Rostami-Hodjegan, Brian…

CertaraSeptember 18, 2024

Publication

A tutorial on PBPK approaches in lactation research

Learn how physiologically based pharmacokinetic modeling can support drug transfer and infant exposure predictions during…

CertaraSeptember 16, 2024

Publication

A tutorial on physiologically based pharmacokinetic approaches in lactation research

The tutorial by Amita Pansari, Xian Pan, Lisa M. Almond, and Karen Rowland-Yeo examines the…

CertaraSeptember 16, 2024

Publication

Intravenous Versus Intraosseous Use of Tranexamic Acid in Patients With Traumatic Brain Injury

See how IV and intraosseous TXA show similar total exposure in prehospital TBI care, analysed…

CertaraSeptember 2, 2024

Publication

Application of physiologically based pharmacokinetic modeling of novel drugs approved by the U.S. food and drug administration

The article from the European Journal of Pharmaceutical Sciences reviews the role of Physiologically Based…

CertaraSeptember 1, 2024

Publication

Utilizing an acute hyperthermia-induced seizure test and pharmacokinetic studies to establish optimal dosing regimens in a mouse model of Dravet syndrome

Learn how triple‑drug combinations increase clobazam metabolite exposure and improve seizure control, modelled using Phoenix…

CertaraAugust 30, 2024

Publication

In Vivo Activity of Intestinal P-Glycoprotein and Hepatic Organic Anion Transporters Polypeptide in Pregnancy and Postpartum

Find out how rosuvastatin exposure increases during pregnancy due to reduced OATP activity, while P‑gp…

CertaraAugust 27, 2024

Modeling and Simulation

On-ramps to popPK: Building Better Models with GUI, Code, or Both

16th Annual World ADC London 2026

A Pharmacokinetic/Toxicodynamic Model of Cisplatin Nephrotoxicity Using the Kidney Injury Molecule‑1 Biomarker

A close examination of BCRP’s role in lactation and methods for predicting drug distribution into milk

A tutorial on PBPK approaches in lactation research

A tutorial on physiologically based pharmacokinetic approaches in lactation research

Intravenous Versus Intraosseous Use of Tranexamic Acid in Patients With Traumatic Brain Injury

Application of physiologically based pharmacokinetic modeling of novel drugs approved by the U.S. food and drug administration

Utilizing an acute hyperthermia-induced seizure test and pharmacokinetic studies to establish optimal dosing regimens in a mouse model of Dravet syndrome

In Vivo Activity of Intestinal P-Glycoprotein and Hepatic Organic Anion Transporters Polypeptide in Pregnancy and Postpartum

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