Using MBMA to run virtual “head-to-head trials” Case Study Using MBMA to run virtual “head-to-head trials” Osteoporosis is common in post-menopausal women. The long-term sequelae of osteoporosis include bone fractures, particularly…CertaraApril 21, 2023
A Bird’s Eye View on Rare Diseases: Key Drug Development Considerations for Thyroid Eye Disease Blog A Bird’s Eye View on Rare Diseases: Key Drug Development Considerations for Thyroid Eye Disease New therapeutics discovery and development for ocular diseases have been traditionally associated with a low…CertaraDecember 15, 2021
Using Model-based Meta-analysis to Inform Neuropathic Pain Drug Development Blog Using Model-based Meta-analysis to Inform Neuropathic Pain Drug Development Model-based Meta-analysis is a framework to compare drugs used to treat diabetic peripheral neuropathy, post-herpetic…CertaraDecember 19, 2019
Apixaban for treatment of venous thromboembolism (VTEtx): Use of MBMA to support Phase 3 dose selection and beyond Publication Apixaban for treatment of venous thromboembolism (VTEtx): Use of MBMA to support Phase 3 dose selection and beyond Apixaban is an orally available, direct, selective inhibitor of the coagulation factor Xa that reversibly…CertaraJune 2, 2018
Model-informed Drug Development for Ixazomib, an Oral Proteasome Inhibitor Publication Model-informed Drug Development for Ixazomib, an Oral Proteasome Inhibitor CertaraFebruary 15, 2018
Drug Asset Evaluation: Increasing “Probability of Success” of a Deal White Paper Drug Asset Evaluation: Increasing “Probability of Success” of a Deal Certara’s due diligence/asset evaluation teams are comprised of drug development and commercialization experts who advise…CertaraAugust 24, 2017
Model-based Meta-analysis: An Innovative Methodology Comes of Age White Paper Model-based Meta-analysis: An Innovative Methodology Comes of Age MBMA integrates internal and external drug development data to inform proprietary commercial and R&D decisions.…CertaraJuly 14, 2016
Short-term Efficacy Reliably Predicts Long-term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model-based Meta-analysis Publication Short-term Efficacy Reliably Predicts Long-term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model-based Meta-analysis The objective of this study was to assess the relationship between short-term and long-term treatment…CertaraJuly 1, 2016
Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis Publication Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis Gastric emptying (GE) is often reported to be slower and more irregular in premature neonates than…CertaraMay 1, 2015
A Model-based Dose-response Meta-analysis of Ocular Hypotensive Agents as a Drug Development Tool to Evaluate New Therapies in Glaucoma Publication A Model-based Dose-response Meta-analysis of Ocular Hypotensive Agents as a Drug Development Tool to Evaluate New Therapies in Glaucoma PURPOSE: To characterize dose and response for intraocular pressure (IOP) reduction and incidence of hyperemia…CertaraMay 1, 2015