Everything You Need to Know About CRFs in Clinical Trials
Read about the basics of CRFs and eCRF design, why annotated CRFs should be standardized…
CertaraMarch 26, 2024
How Clinical Trial Software Helps Make Studies More Efficient
March 13, 2024 Clinical trials play a crucial role in advancing medical research and improving…
CertaraMarch 13, 2024
Guide to development of compound files for PBPK modeling in the Simcyp population-based simulator
The Simcyp Simulator is a software platform for population physiologically-based pharmacokinetic (PBPK) modeling and simulation.…
CertaraFebruary 23, 2024
Interlaboratory Variability in the Madin–Darby Canine Kidney Cell Proteome
Madin–Darby canine kidney (MDCK) cells are widely used to study epithelial cell functionality. Their low…
CertaraJune 28, 2023
More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter-mediated Clearances
Rosuvastatin is a substrate of choice in clinical studies of organic anion-transporting polypeptide (OATP)1B1- and…
CertaraJuly 1, 2016
Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data
A 4-compartment permeability-limited brain (4Brain) model consisting of brain blood, brain mass, cranial and spinal…
CertaraJune 1, 2016
Breast Cancer Resistance Protein Abundance, but Not mRNA Expression, Correlates with Estron e-3-Sulfate Transport in Caco-2
Transporter mRNA and protein expression data are used to extrapolate in vitro transporter kinetics to in…
CertaraApril 1, 2016
