An Evaluation of the Pharmacokinetics of Treprostinil Diethanolamine in Subjects with Hepatic Impairment Publication An Evaluation of the Pharmacokinetics of Treprostinil Diethanolamine in Subjects with Hepatic Impairment Treprostinil diolamine (oral treprostinil) is a prostacyclin analogue under evaluation for the treatment for pulmonary…CertaraDecember 1, 2013
Predicted Heart Rate Effect of Inhaled LABA PF-00610355 in Volunteers and COPD Patients Publication Predicted Heart Rate Effect of Inhaled LABA PF-00610355 in Volunteers and COPD Patients The aim of this study was to assess the cardiovascular effects of a new inhaled…CertaraNovember 1, 2013
Model-supported Development of CS-8635: A Fixed-dose Combination of Olmesartan, Amlodipine, and Hydrochlorothiazide Publication Model-supported Development of CS-8635: A Fixed-dose Combination of Olmesartan, Amlodipine, and Hydrochlorothiazide CS-8635, a fixed-dose triple combination of olmesartan, amlodipine, and hydrochlorothiazide, was developed to address the…CertaraApril 1, 2013
Characterization of Exposure Versus Response of Edoxaban in Patients Undergoing Total Hip Replacement Surgery Publication Characterization of Exposure Versus Response of Edoxaban in Patients Undergoing Total Hip Replacement Surgery Edoxaban is an oral direct factor Xa inhibitor approved for the prevention of venous thromboembolism…CertaraNovember 1, 2012
Population Pharmacokinetics of Vernakalant Hydrochloride Injection (RSD1235) in Patients with Atrial Fibrillation or Atrial Flutter Publication Population Pharmacokinetics of Vernakalant Hydrochloride Injection (RSD1235) in Patients with Atrial Fibrillation or Atrial Flutter Vernakalant hydrochloride is a novel, predominantly atrial-selective antiarrhythmic drug that effectively and rapidly terminates atrial…CertaraJuly 1, 2012
Modeling and Simulation of Edoxaban Exposure and Response Relationships in Patients with Atrial Fibrillation Publication Modeling and Simulation of Edoxaban Exposure and Response Relationships in Patients with Atrial Fibrillation Edoxaban is a novel, orally available, highly specific direct inhibitor of factor Xa and is…CertaraMay 1, 2012
Therapeutic Index of Anticoagulants for Prevention of Venous Thromboembolism Following Orthopedic Surgery: A Dose-response Meta-analysis Publication Therapeutic Index of Anticoagulants for Prevention of Venous Thromboembolism Following Orthopedic Surgery: A Dose-response Meta-analysis Information on the comparative effectiveness of drugs is crucial for drug development decisions, in addition…CertaraDecember 1, 2011
Model-based Development of Anacetrapib, a Novel Cholesteryl Ester Transfer Protein Inhibitor Publication Model-based Development of Anacetrapib, a Novel Cholesteryl Ester Transfer Protein Inhibitor A model-based strategy was used to inform the early clinical development of anacetrapib, a novel…CertaraJune 1, 2011
Systematic Review: Diagnostic Accuracy of Clinical Decision Rules for Venous Thromboembolism in Elderly Publication Systematic Review: Diagnostic Accuracy of Clinical Decision Rules for Venous Thromboembolism in Elderly Physicians committed to the care of elderly patients are challenged with the diagnosis of venous…CertaraApril 1, 2011
Meta-analysis of Thoracic Epidural Anesthesia Versus General Anesthesia for Cardiac Surgery Publication Meta-analysis of Thoracic Epidural Anesthesia Versus General Anesthesia for Cardiac Surgery A combination of general anesthesia (GA) with thoracic epidural anesthesia (TEA) may have a beneficial…CertaraFebruary 1, 2011