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Simcyp™ Biologics

Revolutionizing biologics research and development

Simcyp PBPK Simulator for large molecules

Biological medicines, or biologics, represent a significant portion of the pharmaceutical pipeline, accounting for 30% of new drug approvals and up to 50% of the industry’s pipeline. Unlike small molecules, biologics are larger and have more complexities to their pharmacokinetic and pharmacodynamic properties.

Certara’s Simcyp Biologics platform is specifically designed to address these complexities, enabling scientists to model diverse biologics modalities such as monoclonal antibodies, protein conjugates, Fc-fusion proteins, bispecifics, and other proteins and peptides. 

Predict first-in-human PK and optimize dosing.

Gain insights into complex PK/PD challenges
Address unique challenges in ADC and biologics development

Antibody-drug conjugate (ADC) development

Antibody-drug conjugates (ADCs) are transforming oncology by combining the precision of immunotherapy with the power of small-molecule chemotherapy. These therapies, made of antibodies linked to cell-killing payloads, present unique challenges in pharmacokinetics (PK) and pharmacodynamics (PD) due to their complex structure and the need to analyze multiple molecular species across tissues.

The Simcyp Simulator bridges small and large molecule capabilities, empowering teams to tackle these challenges confidently. By advancing ADC development, it helps bring innovative, life-changing therapies to patients faster.

Accelerating ADC development using Simcyp PBPK

Read our blog to learn the top 10 reasons for using Simcyp PBPK for ADC development.

Schedule a demo

Discover how Simcyp Biologics can transform your biologics development process. Schedule a demo today to explore its advanced modeling capabilities.

Gain insight into complex PK/PD challenges.
Optimize dose selection and first-in-human PK predictions.
Address unique challenges in ADC and biologics development.

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Simcyp Biologics FAQs

What is Simcyp Biologics?

Simcyp Biologics is a modeling platform designed to predict the pharmacokinetics and pharmacodynamics of biologics, enhancing drug development and safety assessments.

How does Simcyp Biologics support ADC development?

The platform integrates small and large molecule capabilities to address the unique PK/PD challenges of ADCs, including tumor penetration and drug-drug interactions (DDIs).

Can Simcyp Biologics model specific populations?

Yes, Simcyp Biologics supports extrapolation to specific populations, such as pediatric and renal impairment groups, ensuring safe and effective treatments.