Blood or Plasma? Which Should You Assay for Drug Concentration? Blog Post
Explore blood vs. plasma drug concentration assays. Learn their differences, relationships, and impact on accurate pharmacokinetic analysis.
Why Should You Evaluate Dose Proportionality? Blog Post
Dose proportionality is a common phrase used pharmacokinetics. Early in the pre-clinical development process, we evaluate dose proportionality in animal species. Then if the drug advances to clinical trials, one...
What is the Difference Between PK and TK? Blog Post
Explore the key differences between pharmacokinetics (PK) and toxicokinetics (TK), their roles in drug development, and their importance.
Why are PK Parameters Lognormally Distributed? Blog Post
The statistical analysis of pharmacokinetic parameters is often overlooked and not always well understood. The disconnect between the pharmacokineticist and the biostatistician can often be a huge stumbling block that…
What are Direct and Indirect Pharmacodynamic Models? Blog Post
When constructing pharmacodynamic (PD) models, you will often encounter the adjectives “direct” and “indirect” describing the associated PD model. This terminology was very confusing to me when I was learning…
What is Modeling and Simulation? Blog Post
I am currently attending a short conference on modeling and simulation in pediatric clinical pharmacology, and I noticed that many people in the conference don’t have a good grasp on…
Physiologically-based Pharmacokinetic Model for Topotecan in Mice Blog Post
Topotecan is a chemotherapeutic agent of choice for the second-line treatment of recurrent ovarian cancer. In this article, we have developed a physiologically based pharmacokinetic model to characterize and predict…
Excretion of the Principal Urinary Metabolites of Phenytoin and Absolute Oral Bioavailability Determined by Use of a Stable Isotope in Patients with Epilepsy Blog Post
The anticonvulsant properties of phenytoin (PHT) were discovered in 1938. Since then, it has been one of the most widely used antiepileptic drugs. It is slowly absorbed, extensively plasma protein-bound,…
Poor Correlation between Urinary Excretion of the Principal Urinary Metabolites of Phenytoin and Absolute Oral Bioavailability Determined by a Stable Isotope Method in Epilepsy Patients Blog Post
The anticonvulsant properties of phenytoin (PHT) were discovered in 1938. Since then, it has been one of the most widely used antiepileptic drugs. It is slowly absorbed, extensively plasma protein-bound,…
Physiologically-based Pharmacokinetics in Drug Development and Regulatory Science Blog Post
The application of physiologically-based pharmacokinetic (PBPK) modeling is coming of age in drug development and regulation, reflecting significant advances over the past 10 years in the predictability of key pharmacokinetic…
