What is Identifiability? Blog Post

Developing models for pharmacokinetic or pharmacodynamic data requires creativity, patience, and hard work. Sometimes that creativity ends up violating mathematical principles which can lead to poorly fitting models and frustration…

Prediction of Overall Survival or Progression Free Survival by Disease Control Rate at Week 8 Is Independent of Ethnicity: Western Versus Chinese Patients with First-line Non-small Cell Lung Cancer Treated with Chemotherapy with or without Bevacizumab Blog Post

Categorizations of best response observed at week 8 of first-line treatment in two studies of bevacizumab plus chemotherapy in Western and Chinese patients with non-small cell lung cancer were assessed together with baseline prognostic factors in multivariate parametric models to predict overall survival and progression free survival.

Using Sampling “Windows” for PK Blood Samples Blog Post

One of the most common questions posed by clinical operations experts when including pharmacokinetic sampling in a clinical trial is the following: “What is the time window we should allow…

What is “Adjusted” r-squared? Blog Post

Linear regression is a common tool that the pharmacokineticist uses to calculate elimination rate constants. Standard linear regression provides estimates for the slope, intercept, and r2, a statistic that helps…