Page 200 | Certara

Publication

The Effects of CYP3A4 Inhibition on Erlotinib Pharmacokinetics: Computer-based Simulation (Simcyp) Predicts In Vivo Metabolic Inhibition

BACKGROUND: Erlotinib is an orally active antitumor agent. Analyses in vitro using human liver microsomes and…

CertaraJanuary 1, 2008

Publication

Physiologically-based Approaches Towards the Prediction of Pharmacokinetics: In Vitro-In Vivo Extrapolation

In adapting to the challenge to make more informed selection of compounds for development, the…

CertaraDecember 1, 2007

Publication

In Silico Elucidation of the Molecular Mechanism Defining the Adverse Effect of Selective Estrogen Receptor Modulators

Early identification of adverse effect of preclinical and commercial drugs is crucial in developing highly…

CertaraNovember 1, 2007

Publication

Comparison of Different Approaches to Predict Metabolic Drug-drug Interactions

Three approaches were compared to predict the actual magnitude of drug interaction (the mean fold-change in the area under…

CertaraOctober 1, 2007

Publication

Prediction of Intestinal First-pass Drug Metabolism

Despite a lower content of many drug metabolising enzymes in the intestinal epithelium compared to…

CertaraOctober 1, 2007

Publication

Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes

An analysis of reported hepatic abundances of CYP3A4 and 3A5 indicated that values determined by…

CertaraOctober 1, 2007

Publication

A Systematic Comparison of Software Dedicated to Meta-analysis of Causal Studies

Our objective was to systematically assess the differences in features, results, and usability of currently…

CertaraSeptember 10, 2007

Publication

Modeling, Simulation, and the Critical Path

The benefits of modeling and simulation fall into two categories: Increased certainty in trial designs…

CertaraSeptember 6, 2007

Publication

Inactivation of CYP2D6 by Methylenedioxymethamphetamine in Different Recombinant Expression Systems

Recombinantly expressed CYP450 systems (rCYPs) are often used to screen for irreversible/quasi-irreversible enzyme inhibitors during…

CertaraSeptember 1, 2007

Publication

Theoretical Assessment of a New Experimental Protocol for Determining Kinetic Values Describing Mechanism (time)-based Enzyme Inhibition

We have shown previously that the conventional experimental protocol (CEP) used to characterise mechanism-based enzyme…

CertaraJuly 1, 2007

The Effects of CYP3A4 Inhibition on Erlotinib Pharmacokinetics: Computer-based Simulation (Simcyp) Predicts In Vivo Metabolic Inhibition

Physiologically-based Approaches Towards the Prediction of Pharmacokinetics: In Vitro-In Vivo Extrapolation

In Silico Elucidation of the Molecular Mechanism Defining the Adverse Effect of Selective Estrogen Receptor Modulators

Comparison of Different Approaches to Predict Metabolic Drug-drug Interactions

Prediction of Intestinal First-pass Drug Metabolism

Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes

A Systematic Comparison of Software Dedicated to Meta-analysis of Causal Studies

Modeling, Simulation, and the Critical Path

Inactivation of CYP2D6 by Methylenedioxymethamphetamine in Different Recombinant Expression Systems

Theoretical Assessment of a New Experimental Protocol for Determining Kinetic Values Describing Mechanism (time)-based Enzyme Inhibition

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