Cassette Dosing: Advantages and Challenges
Cassette dosing is a technique primarily used in drug discovery efforts in non-clinical studies to…
CertaraDecember 16, 2013
Anatomical, Physiological and Metabolic Changes with Gestational Age During Normal Pregnancy: A Database for Parameters Required in Physiologically-based Pharmacokinetic Modeling
Pregnancy is associated with considerable changes in the physiological, anatomical and biochemical attributes in women.…
CertaraDecember 13, 2013
What is GLP (Good Laboratory Practice)?
Good laboratory practice or GLP is a set of principles intended to assure the quality…
CertaraDecember 9, 2013
Bottom-up Modeling and Simulation of Tacrolimus Clearance: Prospective Investigation of Blood Cell Distribution, Sex and CYP3A5 Expression as Covariates and Assessment of Study Power
The objectives were to investigate the ability of population-based in vitro-in vivo extrapolation (IVIVE) to…
CertaraDecember 1, 2013
An Evaluation of the Pharmacokinetics of Treprostinil Diethanolamine in Subjects with Hepatic Impairment
Treprostinil diolamine (oral treprostinil) is a prostacyclin analogue under evaluation for the treatment for pulmonary…
CertaraDecember 1, 2013
Modeling of Pharmacokinetic Systems Using Stochastic Deconvolution
In environments where complete mechanistic knowledge of the system dynamics is not available, a synergy…
CertaraDecember 1, 2013
Differences in Cytochrome P450-mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically-based Pharmacokinetic Modeling
International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH)…
CertaraDecember 1, 2013
Understanding Steady State Pharmacokinetics
Watch our on demand webinar to discover fast, flexible, frictionless PK/PD workflows with Phoenix Cloud.…
CertaraNovember 25, 2013
Absence of Pharmacokinetic Drug-drug Interaction of Pertuzumab with Trastuzumab and Docetaxel
Pertuzumab is a novel antihuman epidermal growth factor receptor 2 (HER2) humanized monoclonal antibody. Combined…
CertaraNovember 24, 2013
Phoenix WinNonlin: A State of the Art Software Tool for Pre-clinical PK and TK Analysis
Are you currently using Excel for PK/TK analysis? Phoenix WinNonlin streamlines analyses and generates all…
CertaraNovember 21, 2013
