Skip to main content

Immuno-oncology Simulator

Immuno-oncology Simulator™: A QSP Platform Model for Immuno-oncology  

An immune-oncology QSP model to inform the next stages of development   

Certara’s IO SimulatorTM predicts the optimal combinations, dose regimens, and biomarkers in virtual patient populations. Selection of the optimal dosing regime and biomarkers for combination therapy in IO requires quantitative consideration of the longitudinal changes in multiple cell populations involved in the Cancer Immunity Cycle. The challenge is determining the optimal combination of dosing regimens and patient stratification biomarkers for specific indications and tumor phenotypes.  

IO Simulator™ is a mechanistic model of the biology underlying the Cancer Immunity Cycle and is delivered in the QSP Designer software. It allows modular development of the compound’s method of action calibrated with pre-clinical data, and integration of this model into the IO Simulator to predict clinical outcomes. Virtual trials with IO SimulatorTM consider tumor heterogeneity and allow predictions of optimal dosing and patient stratification biomarkers for specific indications and tumor phenotypes.  

Modules of IO Simulator™  

  • Tumor, lymph, and blood compartments  
  • Tumor cells  
  • T cells  
  • Dendritic cells  
  • Macrophages  
  • NK cells  
  • Multiple cytokines  

Drug Modalities  

  • mAb  
  • bsAb  
  • ADC  
  • Small molecules  

IO Simulator™ is an ideal drug companion model, where data obtained in the pre-clinical or early clinical stages of drug development are used to refine the model and make predictions informing decisions in the next stage.  

Meet the Expert

Andrzej Kierzek, VP, QSP R&D

Driving innovation in QSP with 25+ years of expertise in molecular and systems biology, leading a team of 20+ scientists to build cutting-edge models and knowledgebases


Talk to a Certara Expert Today

Learn more about our QSP modeling platform for immuno-oncology

Complete the form to book your no-obligation consultation

Resources