Improved Translation of Clinical TCE Dosing with Mechanistic Modeling
Abstract: Regulatory agencies recommend quantitative justifications for clinical dose selection. T-cell engagers (TCE) pose particular…
CertaraOctober 31, 2024
Applications of a QSP Model of LNP mRNA Delivery for the Treatment of Crigler-Najjar Syndrome Type 1
Applications of a QSP Model of LNP mRNA Delivery for the Treatment of Crigler-Najjar Syndrome Type 1
Abstract: Crigler-Najjar syndrome type 1 (CN1) is an autosomal recessive disease caused by a marked…
CertaraOctober 31, 2024
Guiding Target and Lead Optimization for a Molecular Glue Degrader
Learn how to optimize drug properties for protein degrader therapeutics by exploring system characteristics.
CertaraOctober 31, 2024
Capturing CAR T-cell Therapy Dynamics Through Mechanistic Modeling
Abstract: Chimeric antigen receptor T (CAR T)-cell therapy has shown remarkable success in treating various…
CertaraOctober 31, 2024
Physiologically Based Pharmacokinetic Modelling, an Integrative Approach to First in Human (FIH) Studies [APAC Webinar]
Physiologically Based Pharmacokinetic (PBPK) modelling is an integrative approach facilitating the optimal use of various…
CertaraOctober 31, 2024
Early Feasibility Assessment: An Innovative Approach to Gain Confidence in Therapeutic Discovery
In this webinar Josh Apgar, PhD discusses Early Feasibility Assessment (EFA), a quantitative approach to early…
CertaraOctober 29, 2024
Adapting Value Stories for Global Healthcare Markets
Explore how to tailor healthcare value stories to global market access strategies, addressing cultural nuances,…
CertaraOctober 28, 2024
On-ramps to popPK: Building Better Models with GUI, Code, or Both
A critical component of popPK studies is popPK modeling, where mathematical models are developed to…
CertaraOctober 18, 2024
RAPS Sponsored Webcast: Optimizing Pediatric Oncology Drug Development: A Comprehensive Overview
Developing safe and effective oncology medications for children presents unique challenges due to ethical considerations…
CertaraOctober 17, 2024
