Boosting Confidence in Drug Discovery with PBPK 

• • Automation and Documentation Enhancements: New workflow tools such as the Dose Finding Tool streamline and speed up model development and help identify optimal dosing strategies to meet PK/PD targets.
  • Structure-Based Predictors: Use SMILES strings to predict key physicochemical properties.
  • Expanded Static DDI Capabilities: Inclusion of Desipramine (CYP2D6 substrate) and Paroxetine (competitive and mechanism-based CYP2D6 inhibitor) in the static DDI tool.
  • Performance Upgrades: Enhanced user experience with GPT-powered ‘Ask Simcyp’ help and new Simcyp Cloud simulation services.
  • Usability Improvements: Realtime reporting of simulation results withing the Simulator, improved user experience.

Whether you’re a new or experienced user, this session will provide practical insights on how to integrate Simcyp Discovery into your preclinical workflows and stay at the forefront of model-informed drug development.