PK/PD Modeling & Simulation

Adding a Placebo Component to Your PK/PD Model in Phoenix

Nathan Teuscher

PK/PD modeling is an exciting are of research in clinical pharmacology. Most often we try to model the effect of a drug by drawing relationships between the concentration and effect. This usually entails subsetting the data to exclude information from subject that received placebo during the trial. But statistical comparisons in clinical studies are most […]

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Topics: PK/PD Modeling & Simulation

Bioanalytical Calibration Curves

Nathan Teuscher

At the request of a reader, I have decided to extend my series on bioanalysis to include another topic: calibration curves. The calibration curve is they keystone of bioanalysis. It is what links the instrument response to a specific concentration of drug. It is like the magic decoder ring that helps you decipher the hidden […]

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Topics: PK/PD Modeling & Simulation

Bioanalytical Method Validation

Nathan Teuscher

In this final post regarding bioanalysis, I will review a few of the main ideas related to bioanalytical method validation. The purpose of a method validation is to demonstrate that a specific bioanalytical method can reliably determine the concentration of drug in a study sample with a high degree of confidence. Validation does not mean […]

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Topics: PK/PD Modeling & Simulation
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