Adding a Placebo Component to Your PK/PD Model in Phoenix
PK/PD modeling is an exciting are of research in clinical pharmacology. Most often we try…
CertaraAugust 20, 2014
FDA DataFit: an introduction
Explore FDA DataFit, a project ensuring high-quality, compliant data to streamline drug reviews, reduce delays,…
CertaraAugust 19, 2014
Lack of Angiopoietin-like-2 Expression Limits the Metabolic Stress Induced by a High-fat Diet and Maintains Endothelial Function in Mice
Angiopoietin-like-2 (angptl2) is produced by several cell types including endothelial cells, adipocytes and macrophages, and…
CertaraAugust 15, 2014
Bioanalytical Calibration Curves
At the request of a reader, I have decided to extend my series on bioanalysis…
CertaraAugust 12, 2014
Assessment of Tumor Growth Inhibition Metrics to Predict Overall Survival
Modeling and simulation is proposed to support drug development phase transitions in oncology. Longitudinal tumor-size…
CertaraAugust 1, 2014
Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information
We aimed to investigate the application of combined mechanistic pharmacokinetic (PK) and pharmacodynamic (PD) modeling…
CertaraAugust 1, 2014
