Understanding the Effect of the HCV Polymerase Inhibitor Mericitabine on Early Viral Kinetics in the Phase 2 JUMP-C and PROPEL Studies Publication Understanding the Effect of the HCV Polymerase Inhibitor Mericitabine on Early Viral Kinetics in the Phase 2 JUMP-C and PROPEL Studies CertaraAugust 21, 2014
Adding a Placebo Component to Your PK/PD Model in Phoenix Knowledge Base Adding a Placebo Component to Your PK/PD Model in Phoenix PK/PD modeling is an exciting are of research in clinical pharmacology. Most often we try…CertaraAugust 20, 2014
FDA DataFit: an introduction Blog FDA DataFit: an introduction Explore FDA DataFit, a project ensuring high-quality, compliant data to streamline drug reviews, reduce delays,…CertaraAugust 19, 2014
Lack of Angiopoietin-like-2 Expression Limits the Metabolic Stress Induced by a High-fat Diet and Maintains Endothelial Function in Mice Publication Lack of Angiopoietin-like-2 Expression Limits the Metabolic Stress Induced by a High-fat Diet and Maintains Endothelial Function in Mice Angiopoietin-like-2 (angptl2) is produced by several cell types including endothelial cells, adipocytes and macrophages, and…CertaraAugust 15, 2014
Bioanalytical Calibration Curves Knowledge Base Bioanalytical Calibration Curves At the request of a reader, I have decided to extend my series on bioanalysis…CertaraAugust 12, 2014
Comparative Benefit of Malaria Chemoprophylaxis Modeled in United Kingdom Travelers Publication Comparative Benefit of Malaria Chemoprophylaxis Modeled in United Kingdom Travelers CertaraAugust 5, 2014
Assessment of Tumor Growth Inhibition Metrics to Predict Overall Survival Publication Assessment of Tumor Growth Inhibition Metrics to Predict Overall Survival Modeling and simulation is proposed to support drug development phase transitions in oncology. Longitudinal tumor-size…CertaraAugust 1, 2014
Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information Publication Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information We aimed to investigate the application of combined mechanistic pharmacokinetic (PK) and pharmacodynamic (PD) modeling…CertaraAugust 1, 2014