What Does Clearance Mean?
Drug clearance is an extremely important topic in the science of pharmacokinetics. Drug clearance defines…
CertaraJune 13, 2010
Understanding Volume of Distribution
Register for our July 10 webinar and discover fast, flexible, frictionless PK/PD workflows with Phoenix…
CertaraJune 5, 2010
Selection of Alternative CYP3A4 Probe Substrates for Clinical Drug Interaction Studies Using In Vitro Data and In Vivo Simulation
Understanding the potential for cytochrome P450-mediated drug-drug interactions (DDIs) is a critical step in the drug discovery process. DDIs…
CertaraJune 1, 2010
Concentration–Effect Relationships for the Drug of Abuse—γ-hydroxybutyric Acid
γ-Hydroxybutyric acid (GHB) is an endogenous neurotransmitter that is abused because of its sedative/hypnotic and…
CertaraJune 1, 2010
Pharmacology and Safety of Glycerol Phenylbutyrate in Healthy Adults and Adults with Cirrhosis
Phenylbutyric acid (PBA), which is approved for treatment of urea cycle disorders (UCDs) as sodium…
CertaraJune 1, 2010
