PK/PD Modeling & Simulation

What Does Clearance Mean?

Nathan Teuscher

Drug clearance is an extremely important topic in the science of pharmacokinetics. Drug clearance defines how much drug should be administered, how frequently to dose a patient, and how two interacting drugs will affect a patient. The primary PK parameter clearance is very similar to its friend, volume of distribution. Clearance (CL) is a proportionality […]

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Topics: PK/PD Modeling & Simulation

Understanding Volume of Distribution

Nathan Teuscher

One of the most misunderstood pharmacokinetic (PK) parameters is volume of distribution. First of all it has numerous abbreviations (V, Vd, Vz, Vss, V1, Vc, V2, etc.), and to make matters worse, many people incorrectly define the parameter. But, once you understand the meaning behind volume of distribution, you will have a solid grasp on […]

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Topics: PK/PD Modeling & Simulation
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