How LC-MS Proteomics Is Revolutionizing PBPK Modelling and Simulation
Drug-metabolizing enzymes and drug transporters play an important role in hepatic drug metabolism and disposition and therefore have major implications on the fate of drugs in the human body. Recently, an increasing number of studies have reported proteomic expression data for pharmacologically relevant enzymes and transporters providing rich data that can be used for simulation and modelling. However, systematic analysis and understanding of the expression of these proteins in human tissue and commonly used in vitro systems is lacking.
New LC-MS techniques in quantitative proteomics are transforming the approach to quantitative pharmacology and in vitro-in vivo extrapolation (IVIVE) for physiologically-based pharmacokinetic (PBPK) models. In this webinar, Dr. Amin Rostami (Certara) and Dr. Brahim Achour (University of Manchester) discussed the scientific and economic implications of this approach on the IVIVE of enzyme and transporter-mediated drug pharmacokinetics using PBPK models.