A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy Publication A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy This comprehensive review exposes gaps in current knowledge of phase II enzyme and drug transporter…CertaraJanuary 3, 2024
Total and Free Blood and Plasma Concentration Changes in Pregnancy for Medicines Highly Bound to Plasma Proteins: Application of Physiologically Based Pharmacokinetic Modelling to Understand the Impact on Efficacy Publication Total and Free Blood and Plasma Concentration Changes in Pregnancy for Medicines Highly Bound to Plasma Proteins: Application of Physiologically Based Pharmacokinetic Modelling to Understand the Impact on Efficacy For drugs highly bound to plasma proteins, changes in concentrations of free drug may have…CertaraJanuary 3, 2024
Bridging the Gap: Integrating Pharmacometrics with Quantitative Systems Pharmacology (QSP) for Smoother Clinical Phase Transitions On-Demand Webinar Bridging the Gap: Integrating Pharmacometrics with Quantitative Systems Pharmacology (QSP) for Smoother Clinical Phase Transitions Master clinical phase transitions with insights from industry leaders! Join Piet van der Graaf, SVP…CertaraJanuary 2, 2024
Incorporating Pragmatic Elements in Study Designs to Enhance Oncology Randomized Clinical Trials Publication Incorporating Pragmatic Elements in Study Designs to Enhance Oncology Randomized Clinical Trials A FRIENDS OF CANCER RESEARCH WHITE PAPER The article explores the complex landscape of determining…CertaraDecember 19, 2023
Off-Target Drug Safety: Replacing Educated Guesswork with Evidence-Based Risk Assessment On-Demand Webinar Off-Target Drug Safety: Replacing Educated Guesswork with Evidence-Based Risk Assessment Secondary pharmacology profiling involves the screening of small molecule compounds against a broad range of…CertaraDecember 19, 2023
Survival of the Fittest: Evolving Pharmacokinetic Modeling with Pirana On-Demand Webinar Survival of the Fittest: Evolving Pharmacokinetic Modeling with Pirana As regulatory acceptance of models for decision-making grows, so too does the need for optimally…CertaraDecember 19, 2023
Answers to Drug Developers’ Frequent Electronic Common Technical Document Questions Blog Answers to Drug Developers’ Frequent Electronic Common Technical Document Questions Although the Electronic Common Technical Document (eCTD) has been around for many years, it continues…CertaraDecember 12, 2023
Attain FDA Label Claims for Kinase Inhibitor Drugs with the Simcyp™ Simulator Fact Sheet Attain FDA Label Claims for Kinase Inhibitor Drugs with the Simcyp™ Simulator Simcyp was used by pharma and biotech companies to inform, reduce and/or replace clinical studies…CertaraDecember 6, 2023
Pharma Focus Europe – Issue 03 – Using AI to Accelerate Drug Development Press Coverage Pharma Focus Europe – Issue 03 – Using AI to Accelerate Drug Development Authors: Professor Amin Rostami-Hodjegan, Professor Piet van der Graaf This Pharma Focus EU article, co-authored…CertaraDecember 5, 2023
Certara Launches Updated Version of Pirana Modeling Workbench Announcement Certara Launches Updated Version of Pirana Modeling Workbench PRINCETON, N.J.— December 1, 2023 – Certara, Inc., a global leader in biosimulation, today announced…CertaraDecember 1, 2023