pre-update Archives

Publication

Maraviroc: In Vitro Assessment of Drug-drug Interaction Potential

AIMS: To characterize the cytochrome P450 enzyme(s) responsible for the N-dealkylation of maraviroc in vitro,…

CertaraOctober 1, 2008

Publication

Meta-analysis of the Diagnostic Accuracy of Transesophageal Echocardiography for Assessment of Atherosclerosis in the Ascending Aorta in Patients Undergoing Cardiac Surgery

Stroke after cardiac surgery may be caused by emboli emerging from an atherosclerotic ascending aorta…

CertaraOctober 1, 2008

Publication

Accurate and Interpretable Computational Modeling of Chemical Mutagenicity

We describe a method for modeling chemical mutagenicity in terms of simple rules based on…

CertaraSeptember 5, 2008

Publication

Integrating Systems Approaches into Pharmaceutical Sciences

During the first week of December 2007, the European Federation for Pharmaceutical Sciences (EUFEPS) and…

CertaraSeptember 2, 2008

Publication

Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability

This is a summary report of the EUFEPS & COST B25 conference on Bioavailability and…

CertaraAugust 1, 2008

Publication

A Novel Druglike Spleen Tyrosine Kinase Binder Prevents Anaphylactic Shock when Administered Orally

BACKGROUND: The spleen tyrosine kinase (Syk) is recognized as a potential pharmaceutical target for the…

CertaraJuly 1, 2008

Publication

Intestinal Metabolism and Transport of Drugs in Children: The Effects of Age and Disease

The presence of cytochrome P450 enzymes in the small bowel results in the reduced bioavailability…

CertaraJuly 1, 2008

Publication

Pain Relief Model for a COX-2 Inhibitor in Patients with Postoperative Dental Pain

The aim of this study was to develop a pain relief model for a cyclooxygenase…

CertaraJuly 1, 2008

Publication

A Phospho-sugar Binding Domain Homologous to NagB Enzymes Regulates the Activity of the Central Glycolytic Genes Repressor

CggR belongs to the SorC family of bacterial transcriptional regulators which control the expression of…

CertaraJune 1, 2008

Publication

In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and Their Utility for Predicting Drug-drug Interactions

It is widely accepted that today's practice of polypharmacy inevitably increases the incidence of drug-drug…

CertaraJune 1, 2008

pre-update

Maraviroc: In Vitro Assessment of Drug-drug Interaction Potential

Meta-analysis of the Diagnostic Accuracy of Transesophageal Echocardiography for Assessment of Atherosclerosis in the Ascending Aorta in Patients Undergoing Cardiac Surgery

Accurate and Interpretable Computational Modeling of Chemical Mutagenicity

Integrating Systems Approaches into Pharmaceutical Sciences

Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability

A Novel Druglike Spleen Tyrosine Kinase Binder Prevents Anaphylactic Shock when Administered Orally

Intestinal Metabolism and Transport of Drugs in Children: The Effects of Age and Disease

Pain Relief Model for a COX-2 Inhibitor in Patients with Postoperative Dental Pain

A Phospho-sugar Binding Domain Homologous to NagB Enzymes Regulates the Activity of the Central Glycolytic Genes Repressor

In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and Their Utility for Predicting Drug-drug Interactions

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