Publication

Establishment of PK-PD model in anti-inflammatory active components in Inula cappa extract based on lipopolysaccharide-induced in vitro inflammation model

Discover how PK‑PD modelling shows anti‑inflammatory components reduce NO and TNF‑α in inflamed cells using…

CertaraDecember 1, 2022

Publication

Pharmacokinetics and pharmacodynamics of polymyxin B and proposed dosing regimens in elderly patients with multi-drug-resistant Gram-negative bacterial infections

See how fixed 50–75 mg dosing meets PK/PD targets; albumin has minor PK impact using…

CertaraNovember 11, 2022

Publication

Pharmacokinetic and Bioequivalent Study of Potassium Chloride Sustained-Release Tablet Under Different Dietary Conditions in Healthy Chinese Subjects

Learn how urinary potassium excretion comparable across formulations and diets; BE confirmed using Phoenix WinNonlin.

CertaraNovember 2, 2022

Publication

Pharmacokinetics of L-Citrulline in Neonates at Risk of Developing Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension.

Find out how short 16‑min half‑life; simulations support 37–52 mg/kg QID dosing using Phoenix WinNonlin.

CertaraOctober 31, 2022

Publication

Population Pharmacokinetic Analysis of Valsartan in Healthy Chinese Subjects

Explore how food affects absorption; liver enzymes and creatinine influence clearance in valsartan PopPK using…

CertaraOctober 26, 2022

Publication

Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach

Discover how species differences in PK and metabolite ratios explain efficacy variation using Phoenix WinNonlin.

CertaraSeptember 11, 2022

Publication

Early change in the clearance of pembrolizumab reflects the survival and therapeutic response: A population pharmacokinetic analysis in real-world non-small cell lung cancer patients

See how early clearance drop predicts better response and survival; PopPK built using Phoenix NLME.

CertaraSeptember 6, 2022

Publication

Population pharmacokinetics of intravenous colistin sulfate and dosage optimization in critically ill patients

Learn how creatinine clearance and ALT drive PK; simulations show need for adjusted dosing using…

CertaraAugust 29, 2022

Publication

Pharmacokinetic Study of Nalbuphine in Surgical Patients Undergoing General Anesthesia with Varying Degrees of Liver Dysfunction.

Find out how Liver dysfunction increases nalbuphine half‑life and Vd; PK analysed using Phoenix WinNonlin.

CertaraJuly 26, 2022

Publication

Leveraging a Previously Published Population Pharmacokinetic Model to Predict Rivaroxaban Exposure in Real-World Patients

Explore how model predicts population‑level target attainment but large individual variability using Phoenix NLME.

CertaraJuly 25, 2022

Modeling and Simulation

Establishment of PK-PD model in anti-inflammatory active components in Inula cappa extract based on lipopolysaccharide-induced in vitro inflammation model

Pharmacokinetics and pharmacodynamics of polymyxin B and proposed dosing regimens in elderly patients with multi-drug-resistant Gram-negative bacterial infections

Pharmacokinetic and Bioequivalent Study of Potassium Chloride Sustained-Release Tablet Under Different Dietary Conditions in Healthy Chinese Subjects

Pharmacokinetics of L-Citrulline in Neonates at Risk of Developing Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension.

Population Pharmacokinetic Analysis of Valsartan in Healthy Chinese Subjects

Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach

Early change in the clearance of pembrolizumab reflects the survival and therapeutic response: A population pharmacokinetic analysis in real-world non-small cell lung cancer patients

Population pharmacokinetics of intravenous colistin sulfate and dosage optimization in critically ill patients

Pharmacokinetic Study of Nalbuphine in Surgical Patients Undergoing General Anesthesia with Varying Degrees of Liver Dysfunction.

Leveraging a Previously Published Population Pharmacokinetic Model to Predict Rivaroxaban Exposure in Real-World Patients

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