Physiologically-based Mechanistic Modeling to Predict Complex Drug–drug Interactions Involving Simultaneous Competitive and Time-dependent Enzyme Inhibition by Parent Compound and Its Metabolite in Both Liver and Gut—The Effect of Diltiazem on the Time-course of Exposure to Triazolam

Author(s): Karen Rowland Yeo, Masoud Jamei, Jiansong Yang, Geoffrey Tucker, Amin Rostami-Hodjegan
Year: March 18, 2010