The Clinical Utility Index as a Practical Multiattribute Approach to Drug Development Decisions

We identify some innovative approaches to predicting overall patient benefit from investigational drugs to support development decisions. We then illustrate calculation of a probabilistic clinical utility index (CUI), an implementation of multiattribute utility that focuses on clinical attributes.

Author(s): Bill Poland, Lee Hodge, Anis Khan, Robert Clemen, John Wagner, Kevin Dykstra, Rajesh Krishna

Year: July 1, 2009

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