Pharmacokinetics of SN2310, an Injectable Emulsion that Incorporates a New Derivative of SN-38 in Patients with Advanced Solid Tumors

SN2310 is an injectable emulsion composed of vitamin E, a succinate derivative, as well as 7-ethyl-10-hydroxycamptothecin (SN-38), the active metabolite of irinotecan. Single intravenous doses of 15, 20, 25, and 30 mg/m2 of SN2310 emulsion were administered in a total of 26 patients with advanced solid malignancies.

Author(s): Leng Hong Pheng, MyMy Trinh, Howard Burris, Suzanne Jones, Kirsten Anderson, Serina Warner, David Porubek

Year: October 1, 2011