PBPK Modeling of Inter-individual Variability in the Pharmacokinetics of Environmental Chemicals

Generic PBPK models, applicable to a large number of substances, coupled to parameter databases and QSAR modules, are now available for predictive modelling of inter-individual variability in the absorption, distribution, metabolism and excretion of environmental chemicals. When needed, Markov chain Monte Carlo methods and multilevel population models can be jointly used for a Bayesian calibration of a PBPK model, to improve our understanding of the determinants of population heterogeneity and differential susceptibility. This article reviews those developments and illustrates them with recent applications to environmentally relevant questions.

Author(s): Frédéric Bois, Masoud Jamei, Harvey Clewell

Year: December 30, 2010