As part of a collaboration between Medicines for Malaria Venture (MMV), Certara UK and Monash University, physiologically-based pharmacokinetic (PBPK) models were developed for 20 antimalarials, using data obtained from standardized in vitro assays and clinical studies within the literature. The models have been applied within antimalarial drug development at MMV for more than 5 years. During this time…
Development and application of a PBPK modeling strategy to support antimalarial drug development
August 18, 2023
Author(s): Nada Abla, Eleanor Howgate, Karen Rowland-Yeo, Maurice Dickins, Mackenzie C. Bergagnini-Kolev, Kuan-Fu Chen, Savannah McFeely, Jennifer J. Bonner, Laura G. A. Santos, Nathalie Gobeau, Howard Burt, Zoe Barter, Hannah M. Jones, David Wesche, Susan A. Charman, Jörg J. Möhrle, Jeremy N. Burrows, Lisa M. Almond
Year: August 16, 2023