Why download this poster?
When a targeted radiotherapy (TRT) behaves differently in the clinic than preclinical data predict, the gap isn’t always what you expect. This scientific poster from Certara’s SNMMI 2026 presentation reveals how a QSP model built for Pluvicto (¹⁷⁷Lu-PSMA-617) exposed an unexpected, non-PSMA-driven mechanism behind high salivary gland uptake, a finding with direct implications for TRT safety and translation strategy.
Inside, you’ll find:
- A full QSP model architecture for blood, tumor, kidney, and salivary gland compartments
- Mouse-to-human allometric scaling methodology and calibrated simulation results
- Head-to-head hypothesis testing: PSMA-driven vs. non-PSMA uptake mechanisms
- Data visualizations comparing model simulations to published Cycle 1 clinical data (10 patients)
- A strategic roadmap for combining QSP with PBPK to improve TRT translation
Authors:
Sarah Minucci, Bhabuk Koirala, Ben Lang, Jamie Nosbisch, Joshuaine Grant
