Introducing OpenCDISC Enterprise 3.0
Pinnacle 21 is proud to announce the launch of OpenCDISC Enterprise 3.0, which will be…
CertaraOctober 27, 2015
Pharmacokinetics of Tramadol and O-Desmethyltramadol Enantiomers Following Administration of Extended-release Tablets to Elderly and Young Subjects
Tramadol is frequently used in geriatric patients; however, pharmacokinetic (PK) publications on tramadol and O-desmethyltramadol…
CertaraOctober 27, 2015
Development of a Multicompartment Permeability-limited Lung PBPK Model and Its Application in Predicting Pulmonary Pharmacokinetics of Antituberculosis Drugs
Achieving sufficient concentrations of antituberculosis (TB) drugs in pulmonary tissue at the optimum time is still a challenge in…
CertaraOctober 1, 2015
How to Optimize Your Drug Label Using Modeling and Simulation Technology
As a trained pharmacist and scientist, I think a lot about patient care and how…
CertaraSeptember 29, 2015
9 Things Your Boss Wishes You Knew About PK/PD Modeling
Over the course of my career, I have taught the theory and practical applications of PK/PD…
CertaraSeptember 15, 2015
Modeling & Simulation Relating Survival to Tumor Growth Inhibition in Patients
The published OS model and resultant simulations can be leveraged to support Phase II design…
CertaraSeptember 1, 2015
Are Physiologically-based Pharmacokinetic Models Reporting the Right Cmax? Central Venous Versus Peripheral Sampling Site
Physiologically based pharmacokinetic (PBPK) models can over-predict maximum plasma concentrations (Cmax) following intravenous administration. A proposed explanation is that invariably…
CertaraSeptember 1, 2015
Derivation for Logarithmic Trapezoidal AUC Calculation
Calculating area under the curve requires the use of two separate equations: one is follows…
CertaraAugust 5, 2015
Max Kanevsky named to the PharmaVOICE 100 List of the Most Inspiring People
Certara’s Pinnacle 21 is honored to announce that Max Kanevsky, has been named to the…
CertaraAugust 5, 2015
100 Articles That Will Help You Understand PBPK Modeling & Simulation
As a company with a strong academic foundation, our scientists actively publish the results of…
CertaraJuly 28, 2015
