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Drug Interaction Database (DIDB®)

The industry’s largest scientist-curated database for assessing drug interactions and safety

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Optimizing DDI knowledge throughout drug development

The Drug Interaction Database (DIDB®) is the industry’s most comprehensive resource for evaluating drug interactions. Trusted by over 200 pharmaceutical and biotech companies, as well as regulatory agencies, DIDB® provides unparalleled access to qualitative and quantitative human in vitro and clinical data.

By incorporating information on extrinsic and intrinsic factors such as co-medications, excipients, food products, natural products, organ impairment, and genetics, DIDB® enables informed decision-making and supports the development of safer, more effective therapies. 

Drug interactions

100

Publications and NDA/BLA packages analyzed monthly

200

Pharmaceutical and biotech companies worldwide trust DIDB®

210,000

Entries and counting

Streamlines scientific evaluation of drug interactions and safety

Curated daily by a team of research scientists with extensive expertise in drug-drug interactions (DDIs) and pharmacogenetics to maintain a high degree of accuracy, DIDB® enables informed decision-making related to the evaluation of pharmacokinetic (PK)-based drug interactions and safety. A user-friendly interface with pre-formulated query options allows users to efficiently retrieve up-to-date information from a large body of publications and regulatory documentation.

Gain insight on DDI risk & possible clinical outcomes

Prioritize and design clinical trials

Support drug labeling recommendations

Explore DIDB’s dynamic research tools and applications

Retrieve DDI information with 70+ pre-formulated queries

Search the DIDB using multiple query options.

Easily filter query for metadata analysis

Perform metadata analysis of quantitative results using common metrics across all studies.

Explore in-depth drug monographs

Review mechanistic and quantitative findings such as PK profile, DDI summary, and QT summary, as well as overall DDI risk level and label recommendations for clinical use.

Support static predictions and PBPK modeling

Use query results to guide input parameter selection and provide context for results obtained for candidate compounds.

Quickly calculate clinical DDI risk

Explore the clinical DDI risk of a compound acting as a precipitant or perpetrator based on a compound’s properties and early in vitro results using with the drug-drug interaction (DDI) calculator.

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Support personalized medicine approaches with custom extracts

Leverage DIDB® to create custom extracts that support tailored therapeutic approaches for individual patients.

Why Certara

Why choose DIDB

Certara’s DIDB is the largest scientist-curated collection of human in vitro and clinical data available to assess drug interactions and safety.

  • 27,000+ citations from all relevant publications and FDA regulatory documents
  • 630+ NDA/BLA packages available with new approvals added monthly
Drug interactions

“DIDB is an amazing resource. It streamlines our research of pharmacokinetic parameters for individual drugs and has cut down our time to evaluate a medication by at least 50%. The team there is responsive to questions, and they have a nice training program to orient you to the tool. The ability to filter drug data in a seemingly infinite number of ways is a key feature.”

Senior Vice President of Medical AffairsPharmacogenetics and Personalized Medicine Service Provider, USA

“The DIDB is a precious tool for clinical pharmacologists; it is of invaluable help for drug-drug interactions, but there is much more with all the available resources, monographs, and information on PK effects of hepatic and renal impairment, side and pharmacodynamic effects.”

Senior DirectorBiosimulation Services Provider, Italy

“We are using online searches in DIDB for robust planning and upfront modeling of in vitro experiments, e.g., for optimizing choices of DME phenotyping inhibitors. The fast and sophisticated access to the complete in vitro dataset, available from the scientific community, facilitates the design of such in vitro studies tremendously.”

Associate Director, Senior DMPK ExpertPreclinical Service Provider, Germany

Explore additional DIDB and drug interaction resources

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Brochure

Human in vitro Drug Metabolism Dataset

The Drug Metabolism Dataset contains results from in vitro metabolism studies, where a drug is tested as an inhibitor/activator/inducer (precipitant) or a substrate (object) for a given human drug metabolizing enzyme (including variants).
Read more
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On-Demand Webinar

The Future of DIDB

Explore the future of the Drug Interaction Database (DIDB) in this on-demand webinar, featuring insights on advancements, trends, and expert predictions.
Watch now
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White Paper

Assessing Transporter-Mediated DDIs

Discover strategies for evaluating transporter-mediated drug-drug interactions (DDIs) and their impact on drug safety, efficacy, and regulatory assessment.
Read more

Schedule a demo or request a free trial

Discover how DIDB® can transform your drug development process. Schedule a demo or request a free trial today to explore its advanced features and capabilities.

Access the industry’s largest scientist-curated drug interaction database.
Retrieve and analyze data with over 70 pre-formulated queries.
Explore in-depth drug monographs.

FAQs

What is DIDB?

DIDB is the world’s largest scientist-curated database for evaluating drug interactions, used by over 200 pharmaceutical and biotech companies.

What type of information is included in DIDB?

DIDB includes both qualitative and quantitative human in vitro and clinical information related to various extrinsic and intrinsic factors. These include interacting co-medications, excipients, food products, herbals, tobacco, organ impairment, and genetics, that can affect drug exposure in humans.

How often is DIDB updated?

DIDB is updated daily by a team of expert scientists to ensure accuracy and relevance.

What are the main mechanisms of DDI covered in DIDB?

DIDB includes mainly metabolism- and transporter-based pharmacokinetic interactions. However, other mechanisms (e.g. absorption-based DDIs, pharmacogenetics, food effects, hepatic and renal impairment) are also covered. Pharmacodynamic interactions which cannot be explained by changes in drug or metabolite exposure are not included.

Can DIDB support personalized medicine?

Yes, DIDB enables the creation of custom extracts to support personalized therapeutic approaches.