Dose correction for the Michaelis-Menten approximation of the target – mediated drug disposition model.

The Michaelis-Menten (M-M) approximation of the target-mediated drug disposition (TMDD) pharmacokinetic (PK) model was derived based on the rapid binding (RB) or quasi steady-state (QSS) assumptions that implied that the target and drug binding and dissociation were in equilibrium. However, the initial dose for an IV bolus injection for the M-M model did not account for a fraction bound to the target.

 

Xiaoyu Yan, Wojciech Krzyzanski,
August 23, 2012
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