New Horizons of Model Informed Drug Development in Rare Diseases Drug Development
Model-informed drug development is revolutionizing the way we approach rare diseases, where traditional large-scale clinical…
CertaraJuly 11, 2024
A literature review of drug transport mechanisms during lactation
The literature review titled "A literature review of drug transport mechanisms during lactation," authored by…
CertaraJuly 7, 2024
pyDarwin machine learning algorithms application and comparison in nonlinear mixed-effect model selection and optimization
Dr. Mark Sale, Dr. Keith Nieforth, James Craig and peers from industry, healthcare, and academia…
CertaraJune 28, 2024
Dose Optimization Informed by PBPK Modeling: State-of-the Art and Future
The article "Dose Optimization Informed by PBPK Modeling: State-of-the Art and Future" by Karen Rowland…
CertaraMay 6, 2024
Prediction of Pediatric Pharmacokinetics for CYP3A4 Metabolized Drugs: Comparison of the Performance of Two Hepatic Ontogeny Within a Physiologically Based Pharmacokinetic Model
The rapid growth in the use of pediatric physiologically based pharmacokinetic (PBPK) models, particularly for…
CertaraMay 6, 2024
Multi-phase multi-layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin
Physiologically-based pharmacokinetic models combine knowledge about physiology, drug product properties, such as physicochemical parameters, absorption,…
CertaraApril 26, 2024
