Publication Archives

Publication

Real-world application of physiologically based pharmacokinetic models in drug discovery

The utility of physiologically based pharmacokinetic (PBPK) models in support of drug development has been…

CertaraNovember 22, 2024

Publication

Predicting clinical outcomes from off-target receptor interactions using Secondary Intelligence™

Publication: Journal of Pharmacological and Toxicological Methods Adverse effects due to off-target activity can be predicted…

CertaraNovember 20, 2024

Publication

Recent applications of pharmacometrics and systems pharmacology approaches to improve and optimize drug therapy for pregnant and lactating women

The article "Recent Applications of Pharmacometrics and Systems Pharmacology Approaches to Improve and Optimize Drug…

CertaraNovember 18, 2024

Publication

ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation

Abstract Immune checkpoint inhibitors (ICI) have transformed cancer treatment. However, only a minority of patients…

CertaraNovember 13, 2024

Publication

A Sequential Population Pharmacokinetic Model of Zilovertamab Vedotin in Patients with Hematologic Malignancies Extrapolated to the Pediatric Population

CertaraNovember 7, 2024

Publication

Informing pregnancy dose via target-mediated drug disposition modeling and simulations for a recombinant human monoclonal antibody

The article titled "Informing pregnancy dose via target-mediated drug disposition modeling and simulations for a…

CertaraNovember 4, 2024

Publication

Using PBPK modeling to supplement clinical data and support the safe and effective use of dolutegravir in pregnant and lactating women

The article titled "Using PBPK modeling to supplement clinical data and support the safe and…

CertaraOctober 30, 2024

Publication

Quantitative systems pharmacology model of GITR-mediated T cell dynamics in tumor microenvironment

Abstract: T cell interaction in the tumor microenvironment is a key component of immuno-oncology therapy.…

CertaraOctober 29, 2024

Publication

Early Feasibility Assessment: A Method for Accurately Predicting Biotherapeutic Dosing to Inform Early Drug Discovery Decisions

Early Feasibility Assessment (EFA) can impact early drug discovery decisions such as determining feasibility of…

CertaraOctober 29, 2024

Publication

Medicines in pregnancy: A clinical pharmacology extrapolation framework to address knowledge gaps

CertaraOctober 16, 2024

Publication

Real-world application of physiologically based pharmacokinetic models in drug discovery

Predicting clinical outcomes from off-target receptor interactions using Secondary Intelligence™

Recent applications of pharmacometrics and systems pharmacology approaches to improve and optimize drug therapy for pregnant and lactating women

ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation

A Sequential Population Pharmacokinetic Model of Zilovertamab Vedotin in Patients with Hematologic Malignancies Extrapolated to the Pediatric Population

Informing pregnancy dose via target-mediated drug disposition modeling and simulations for a recombinant human monoclonal antibody

Using PBPK modeling to supplement clinical data and support the safe and effective use of dolutegravir in pregnant and lactating women

Quantitative systems pharmacology model of GITR-mediated T cell dynamics in tumor microenvironment

Early Feasibility Assessment: A Method for Accurately Predicting Biotherapeutic Dosing to Inform Early Drug Discovery Decisions

Medicines in pregnancy: A clinical pharmacology extrapolation framework to address knowledge gaps

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